Non-oxidative pentose phosphate pathway controls regulatory T cell function by integrating metabolism and epigenetics

Affiliations

• 1 Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
• 2 Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
• 3 Department of Microbiology, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
• 4 School of Pharmaceutical Sciences, Tsinghua University, Beijing, China.
• 5 Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.
• 6 Department of Pathology, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
• 7 Department of Rheumatology and Immunology, Changzheng Hospital, Second Military Medical University, Shanghai, China.
• 8 Department of Orthopedics, Changhai Hospital, Second Military Medical University, Shanghai, China.
• 9 Shanghai Ninth People's Hospital, Department of Clinical Laboratories, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
• 10 Center for Brain Science of Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
• 11 Department of Anatomy and Physiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
• 12 Molecular and Cell Biology Lab of Key Laboratory of Molecular Medicine of Ministry of Education and Institutes of Biomedical Sciences, Shanghai Medical College, College of Life Science, Fudan University, Shanghai, China.
• 13 Department of Neurosurgery, Huashan Hospital, Institute for Translational Brain Research, Shanghai Key laboratory of Brain Function Restoration and Neural Regeneration, Shanghai Clinical Medical Center of Neurosurgery, MOE Frontiers Center for Brain Science, Shanghai Medical College, Fudan University, Shanghai, China. hui_yang@fudan.edu.cn.
• 14 Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China. binli@shsmu.edu.cn.
• 15 Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China. xuemeitong@shsmu.edu.cn.
• # Contributed equally.