1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. Transketolase

Transketolase (转酮酶)

Transketolase

Transketolase 是磷酸戊糖途径 (PPP) 非氧化分支中的关键限速酶。Transketolase 对于能量转导和产生用于核酸合成的核糖至关重要。Transketolase 可以将核酮糖 5-磷酸转化回葡萄糖 6-磷酸以产生更多的 NADPH,并且该反应是硫胺素依赖性的。Transketolase 有三种异构体:TKT、TKTL1和TKTL2。TKT 在所有研究的生物体中均有表达,并在多种癌症类型中上调[1][2]

Transketolase is a key rate-limiting enzyme in the non-oxidative branch of the pentose phosphate pathway (PPP). Transketolase is critical for energy transduction and for generating ribose for nucleic acid synthesis. Transketolase can convert ribulose 5-phosphate back into glucose 6-phosphate to generate more NADPH, and the reaction is thiamine-dependent. Transketolase has three isomer: TKT, TKTL1 and TKTL2. TKT is expressed in all investigated organisms, and is up-regulated in multiple cancer types[1][2].

Transketolase 相关产品 (9):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-16339
    N3PT Inhibitor 99.56%
    N3PT (N3-pyridyl thiamine) 是转酮醇酶 (transketolase) 抑制剂。N3PT 通过焦磷酸化来结合转酮醇酶,对缺少结合型硫胺素转酮酶 (Apo-TK) 的 Kd 为 22 nM。
    N3PT
  • HY-139731
    Transketolase-IN-1 Inhibitor 99.06%
    Transketolase-IN-1是一种很有希望的除草剂,可用于小麦和玉米田的杂草防治,其作用靶点为 Transketolase
    Transketolase-IN-1
  • HY-112889B
    Oxythiamine diphosphate ammonium Inhibitor
    Oxythiamin diphosphate ammonium 是一种有效的转酮酶 (TK) 抑制剂。
    Oxythiamine diphosphate ammonium
  • HY-151600
    Transketolase-IN-2 Inhibitor 99.83%
    Transketolase-IN-2 (化合物 4w) 是一种强效的 Transketolase 抑制剂。Transketolase-IN-2 对 Digitaria sanguinalis 和 Amaranthus retroflexus 显示出较强的抑制作用 (在 200 mg/L 时抑制率超过 90%,在 100 mg/L 时抑制率约为 80%)。Transketolase-IN-2 可用于杂草防治的研究。
    Transketolase-IN-2
  • HY-151604
    Transketolase-IN-3 Inhibitor 98.52%
    Transketolase-IN-3 是一种有效的转酮酶 (TK) 抑制剂。Transketolase-IN-3 具有除草活性,对血红木 (DS) 和苋菜 (AR) 具有抑制作用。Transketolase-IN-3 可用于除草剂的研究。
    Transketolase-IN-3
  • HY-112889
    Oxythiamine diphosphate
    Oxythiamine diphosphate是焦磷酸硫胺的竞争性抑制剂,Ki 值为30 nM。
    Oxythiamine diphosphate
  • HY-E70075
    α-Glycerophosphate Dehydrogenase-Triosephosphate

    α-甘油磷酸脱氢酶-磷酸丙糖异构酶

    α-Glycerophosphate Dehydrogenase-Triosephosphate (GDH-TIM) 是一种由甘油磷酸脱氢酶 (GDH) 和三磷酸异构酶 (TIM) 组成的酶混合物。α-Glycerophosphate Dehydrogenase-Triosephosphate 可用于测定红细胞溶血物中的转酮醇酶 (TK) 活性,以评估维生素 B 缺乏症。
    α-Glycerophosphate Dehydrogenase-Triosephosphate
  • HY-163311
    Transketolase-IN-6
    Transketolase-IN-6 (Compound 6bj) 是一种除草剂先导化合物。Transketolase-IN-6 对反枝苋 (Amaranthus retroflexus) 和狗尾草 (Setaria viridis) 具有约 80% 的根部抑制作用。Transketolase-IN-6 是一种有效的转酮酶 (TK) 抑制剂。
    Transketolase-IN-6
  • HY-163310
    Transketolase-IN-5 Inhibitor
    Transketolase-IN-5 (compound 6ba) 是一种转酮酶 (transketolase) 抑制剂。Transketolase-IN-5 显示对Amaranthus retroflexus, Setariaviridis, Digitaria sanguinalis 的除草剂活性。
    Transketolase-IN-5