2. Academic Validation
  3. One-pot synthesis of α-Linolenic acid nanoemulsion-templated drug-loaded silica mesocomposites as efficient bactericide against drug-resistant Mycobacterium tuberculosis

One-pot synthesis of α-Linolenic acid nanoemulsion-templated drug-loaded silica mesocomposites as efficient bactericide against drug-resistant Mycobacterium tuberculosis

  • Eur J Pharm Sci. 2022 Sep 1;176:106261. doi: 10.1016/j.ejps.2022.106261.
Ping Zhu 1,  Ling Cai 1,  Qiao Liu 2,  Shanwu Feng 3,  Hongjie Ruan 3,  Li Zhang 1,  Liuzhu Zhou 1,  Huijun Jiang 4,  Hongsheng Wang 5,  Jianming Wang 6,  Jin Chen 7
Affiliations

Affiliations

  • 1 Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, China.
  • 2 Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, China; Department of Chronic Communicable Disease, Center for Disease Control and Prevention of Jiangsu Province, Nanjing, China.
  • 3 Women's Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, 123 Tianfei Lane, Nanjing 210004, China.
  • 4 School of Pharmacy, Nanjing Medical University, Nanjing 211166, China.
  • 5 Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, China; Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, St. 12 Jiangwangmiao, Nanjing 210042, China. Electronic address: whs33@vip.sina.com.
  • 6 Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, China. Electronic address: jmwang@njmu.edu.cn.
  • 7 Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, China; Jiangsu Province Engineering Research Center of Antibody Drug, Key Laboratory of Antibody Technique of National Health Commission, Nanjing Medical University, Nanjing 211166, China; The Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing 211166, China; Xinjiang Production & Construction Corps Key Laboratory of Protection and Utilization of Biological Resources in Tarim Basin, Tarim University, Alar 843300, China. Electronic address: jchen@njmu.edu.cn.
PMID: 35840102 DOI: 10.1016/j.ejps.2022.106261
Abstract

Nowadays, pathogenic Infection has posed a severe threat to the public health and environmental sanitation, urging a continuous search of efficacious and safe bactericidal agents of various formulated forms. Here, a facile one-pot hydrothermal preparation of mesoporous silica nanoparticles using ultrasonication-assisted nanoemulsion of α-Linolenic acid (α-LA) as template was developed. The formed silica mesocomposite at water/fatty-acid surface provides an easy yet green synthesis route, which can be generalized for the further encapsulation of hydrophobic drugs such as antimycobacterial Rifampicin (RIF). The obtained α-LA nanoemulsion-templated silica nanoparticles (LNS NPs), with a weight content of ∼17% α-LA in the composite, showed apparent Antibacterial effect against Staphylococcus aureus (S. aureus). By comparison, the removal of α-LA from the silica nanoparticles (LNS-1 NPs) resulted in the composite of enlarged pore size with negligible bactericidal activities. Notably, the Isoniazide (INH) and Rifampicin (RIF)-encapsulated LNS NPs exhibited outstanding antimycobacterial activity against both drug-sensitive and drug-resistant Mycobacterium tuberculosis (M. tuberculosis). The obtained highly biocompatible, biosafe and low-energy consumptive α-LA-contained mesostructured silica-based bactericide holds promising therapeutic potentials to tackle the emerging drug-resistant infectious microbes.

Keywords

Antibacterial agent; Drug-resistant Mycobacterium tuberculosis; Fatty acid; Mesoporous silica nanoparticles; Nanoemulsions.

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