1. Academic Validation
  2. Engineering micro oxygen factories to slow tumour progression via hyperoxic microenvironments

Engineering micro oxygen factories to slow tumour progression via hyperoxic microenvironments

  • Nat Commun. 2022 Aug 2;13(1):4495. doi: 10.1038/s41467-022-32066-w.
Weili Wang  # 1 Huizhen Zheng  # 1 Jun Jiang 1 Zhi Li 2 Dongpeng Jiang 3 Xiangru Shi 3 Hui Wang 1 Jie Jiang 1 Qianqian Xie 1 Meng Gao 1 Jianhong Chu 3 Xiaoming Cai 4 Tian Xia 5 Ruibin Li 6
Affiliations

Affiliations

  • 1 State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Suzhou Medical College, Soochow University, Suzhou, Jiangsu, 215123, China.
  • 2 Department of Interventional Radiology, the First Affiliated Hospital of Soochow University, Soochow University, Suzhou, Jiangsu, 215001, China.
  • 3 Institute of Blood and Marrow Transplantation, National Clinical Research Center for Hematologic Diseases, Soochow University, Suzhou, China.
  • 4 School of Public Health, Suzhou Medical College, Soochow University, Suzhou, Jiangsu, 215123, China.
  • 5 Division of NanoMedicine, Department of Medicine, California Nanosystems Institute, University of California, Los Angeles, CA, 90095, USA.
  • 6 State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Suzhou Medical College, Soochow University, Suzhou, Jiangsu, 215123, China. liruibin@suda.edu.cn.
  • # Contributed equally.
Abstract

While hypoxia promotes carcinogenesis, tumour aggressiveness, metastasis, and resistance to oncological treatments, the impacts of hyperoxia on tumours are rarely explored because providing a long-lasting oxygen supply in vivo is a major challenge. Herein, we construct micro oxygen factories, namely, photosynthesis microcapsules (PMCs), by encapsulation of acquired cyanobacteria and upconversion nanoparticles in alginate microcapsules. This system enables a long-lasting oxygen supply through the conversion of external radiation into red-wavelength emissions for photosynthesis in cyanobacteria. PMC treatment suppresses the NF-kB pathway, HIF-1α production and Cancer cell proliferation. Hyperoxic microenvironment created by an in vivo PMC implant inhibits hepatocarcinoma growth and metastasis and has synergistic effects together with anti-PD-1 in breast Cancer. The engineering oxygen factories offer potential for tumour biology studies in hyperoxic microenvironments and inspire the exploration of oncological treatments.

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