2. Academic Validation
  3. Phoenixin 14 ameloriates pancreatic injury in streptozotocin-induced diabetic rats by alleviating oxidative burden

Phoenixin 14 ameloriates pancreatic injury in streptozotocin-induced diabetic rats by alleviating oxidative burden

  • J Pharm Pharmacol. 2022 Nov 4;74(11):1651-1659. doi: 10.1093/jpp/rgac055.
Zarife Nigâr Ozdemir-Kumral 1,  Eminenur Sen 2,  Hasan Basri Yapici 2,  Nurullah Atakul 2,  Omer Faruk Domruk 2,  Yusra Aldag 2,  Leyla Semiha Sen 1 3,  Fatma Kanpalta Mustafaoğlu 4,  Meral Yuksel 5,  Dilek Akakin 4,  Can Erzik 6,  Goncagul Haklar 7,  Neşe Imeryuz 1
Affiliations

Affiliations

  • 1 Department of Physiology, Marmara University School of Medicine, Istanbul, Turkey.
  • 2 Marmara University School of Medicine, Istanbul, Turkey.
  • 3 Department of General Surgery, Marmara University School of Medicine, Istanbul, Turkey.
  • 4 Department of Histology and Embryology, Marmara University School of Medicine, Istanbul, Turkey.
  • 5 Department of Medical Laboratory Technics, Marmara University Vocational School of Health Services, Istanbul, Turkey.
  • 6 Department of Medical Biology, Marmara University School of Medicine, Istanbul, Turkey.
  • 7 Department of Biochemistry, Marmara University School of Medicine, Istanbul, Turkey.
PMID: 36130115 DOI: 10.1093/jpp/rgac055
Abstract

Phoenixin-14 (PNX) is a neuropeptide that has been shown to prevent oxidative damage and stimulates Insulin secretion. We investigated the effects of PNX on pancreatic injury induced by streptozotocin (STZ), and nicotinamide (NAD). Male Sprague-Dawley rats, in control (C) and diabetic (STZ) groups, were treated with either saline, or PNX (0.45 nmol/kg, or 45 nmol/kg) daily for 3 days 1 week after STZ injection. Fasting blood glucose (FBG) and gastric emptying rate (GER) were measured. Tissue and blood samples were collected. PNX treatments prevented pancreatic damage and β cell loss. Increased luminol and lucigenin levels in the pancreas, ileum and liver tissues of STZ groups were alleviated by PNX treatment in pancreatic and ileal tissues. PNX0.45 decreased FBG without any change in Insulin blood level and pancreatic mRNA. GER increased in all diabetic rats while PNX0.45 delayed GER only in the C group. PNX diminishes pancreatic damage and lowers FBG by reducing oxidative load.

Keywords

MPO; free radicals; gastric emptying; glucose; inflammation; insulin.

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