1. Academic Validation
  2. Small molecule-assisted assembly of multifunctional ceria nanozymes for synergistic treatment of atherosclerosis

Small molecule-assisted assembly of multifunctional ceria nanozymes for synergistic treatment of atherosclerosis

  • Nat Commun. 2022 Nov 1;13(1):6528. doi: 10.1038/s41467-022-34248-y.
Xiaoxue Fu 1 Xiaojuan Yu 1 Junhao Jiang 1 Jiaxin Yang 1 Lu Chen 1 Zhangyou Yang 2 Chao Yu 3
Affiliations

Affiliations

  • 1 Chongqing Key Laboratory for Pharmaceutical Metabolism Research, Chongqing Pharmacodynamic Evaluation Engineering Technology Research Center, College of Pharmacy, Chongqing Medical University, 400016, Chongqing, P. R. China.
  • 2 Chongqing Key Laboratory for Pharmaceutical Metabolism Research, Chongqing Pharmacodynamic Evaluation Engineering Technology Research Center, College of Pharmacy, Chongqing Medical University, 400016, Chongqing, P. R. China. yangzhangyou@cqmu.edu.cn.
  • 3 Chongqing Key Laboratory for Pharmaceutical Metabolism Research, Chongqing Pharmacodynamic Evaluation Engineering Technology Research Center, College of Pharmacy, Chongqing Medical University, 400016, Chongqing, P. R. China. yuchao@cqmu.edu.cn.
Abstract

Considering that intravascular Reactive Oxygen Species (ROS) and inflammation are two characteristic features of the atherosclerotic microenvironment, developing an appropriate strategy to treat atherosclerosis by synergistically regulating ROS and inflammation has attracted widespread attention. Herein, a special molecule, zoledronic acid, containing imidazole and bisphosphonate groups, was selected for the first time to assist the assembly of cerium ions and produce functionalized ceria-zoledronic acid nanocomposites (CZ NCs). It not only serves as a new carrier for different kinds of drugs (e.g. probucol, PB) but also exerts an efficient multienzyme activity to achieve collaborative therapy. More importantly, platelet membrane-coated biomimetic nanoplatform (PCZ@PB NCs) specifically accumulate at inflammatory atherosclerotic lesions, synergistically regulate ROS levels and inflammation, and efficiently inhibit foam cell formation. This novel assembly method can also be applied in the treatment of many Other Diseases associated with oxidative stress and inflammation.

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