2. Academic Validation
  3. Macrophages regulate vascular smooth muscle cell function during atherosclerosis progression through IL-1β/STAT3 signaling

Macrophages regulate vascular smooth muscle cell function during atherosclerosis progression through IL-1β/STAT3 signaling

  • Commun Biol. 2022 Dec 1;5(1):1316. doi: 10.1038/s42003-022-04255-2.
Yuzhou Xue # 1 2,  Minghao Luo # 1,  Xiankang Hu 1,  Xiang Li 1,  Jian Shen 1,  Wenyan Zhu 3 4,  Longxiang Huang 1,  Yu Hu 1,  Yongzheng Guo 1,  Lin Liu 5,  Lingbang Wang 6,  Suxin Luo 7
Affiliations

Affiliations

  • 1 Department of Cardiology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
  • 2 Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, Beijing, China.
  • 3 Medical Department, Yidu Cloud (Beijing) Technology Co., Ltd., Beijing, China.
  • 4 Chongqing Engineering Research Center of Pharmaceutical Sciences, Chongqing Medical and Pharmaceutical College, Chongqing, China.
  • 5 Department of Dermatology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
  • 6 Department of Orthopedic Surgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
  • 7 Department of Cardiology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China. luosuxin0204@163.com.
  • # Contributed equally.
PMID: 36456628 DOI: 10.1038/s42003-022-04255-2
Abstract

Vascular smooth muscle cells (VSMCs) play a central role in atherosclerosis progression, but the functional changes in VSMCs and the associated cellular crosstalk during atherosclerosis progression remain unknown. Here we show that scRNA-seq analysis of proximal adjacent (PA) and atherosclerotic core (AC) regions of human carotid artery plaques identifies functional alterations in macrophage-like VSMCs, elucidating the main state differences between PA and AC VSMCs. And, IL-1β mediates macrophage-macrophage-like VSMC crosstalk through regulating key transcription factors involved in macrophage-like VSMCs functional alterations during atherosclerosis progression. In vitro assays reveal VSMCs trans-differentiated into a macrophage-like phenotype and then functional alterations in response to macrophage-derived stimuli. IL-1β promots the adhesion, inflammation, and Apoptosis of macrophage-like VSMCs in a STAT3 dependent manner. The current findings provide interesting insight into the macrophages-macrophage-like VSMC crosstalk, which would drive functional alterations in the latter cell type through IL-1β/STAT3 axis during atherosclerosis progression.

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