The Highly Potent AhR Agonist Picoberin Modulates Hh-Dependent Osteoblast Differentiation

Affiliations

• 1 Department of Chemical Biology, Max Planck Institute of Molecular Physiology, Dortmund 44227, Germany.
• 2 Faculty of Chemistry, Chemical Biology, Technical University Dortmund, Dortmund 44227, Germany.
• 3 Faculty of Chemistry, Institute of Organic Chemistry, University of Vienna Währinger Str. 38, Vienna 1090, Austria.
• 4 Key Laboratory of Birth Defects and Related Diseases of Women and Children, Evidence-Based Pharmacy Center, West China Second University Hospital, Sichuan University, Chengdu 610041, China.
• 5 Ludwig Institute for Cancer Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 7DQ, United Kingdom.
• 6 Nuffield Department of Medicine, Target Discovery Institute, University of Oxford, Oxford, OX3 7FZ, UK.
• 7 Protein Chemistry Facility, Max Planck Institute of Molecular Physiology, Dortmund 44227, Germany.
• 8 Faculty of Chemistry, Inorganic Chemistry, Technical University Dortmund, Dortmund 44227, Germany.
• 9 Dept. of Pharmaceutical & Medicinal Chemistry, Institute of Pharmacy, Christian-Albrechts-University of Kiel, Kiel 24118, Germany.
• 10 Department of Chemistry and Forensics, School of Science and Technology, Nottingham Trent University, Clifton Lane, Nottingham, NG11 8NS, United Kingdom.
• 11 Compound Management and Screening Center, Dortmund 44227, Germany.
• 12 i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugal.
• 13 IBMC-Instituto de Biologia Molecular e Celular, Universidade do Porto, 4200-135 Porto, Portugal.