2. Academic Validation
  3. Construction of pH-responsive polydopamine coated magnetic layered hydroxide nanostructure for intracellular drug delivery

Construction of pH-responsive polydopamine coated magnetic layered hydroxide nanostructure for intracellular drug delivery

  • Eur J Pharm Biopharm. 2022 Nov 30;S0939-6411(22)00283-1. doi: 10.1016/j.ejpb.2022.11.024.
Zhaoyun Liu 1,  Xi Wang 2,  Xiaoxu Chen 3,  Liu Cui 1,  Ziqi Li 1,  Ziwei Bai 1,  Kui Lin 4,  Jian Yang 5,  Fei Tian 6
Affiliations

Affiliations

  • 1 State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, P.R. China; Tianjin Key Laboratory of TCM Chemistry and Analysis, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, P.R. China.
  • 2 State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, P.R. China; Haihe Laboratory of Modern Chinese Medicine, Tianjin 301617, P.R. China.
  • 3 Department of Pharmacy, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, P.R. China.
  • 4 Analytical Instrumentation Centre, Tianjin University, Tianjin, 300072, P.R. China.
  • 5 State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, P.R. China; Haihe Laboratory of Modern Chinese Medicine, Tianjin 301617, P.R. China. Electronic address: yang.j2017@tjutcm.edu.cn.
  • 6 State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, P.R. China; Tianjin Key Laboratory of TCM Chemistry and Analysis, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, P.R. China. Electronic address: tianfei.louise@163.com.
PMID: 36462716 DOI: 10.1016/j.ejpb.2022.11.024
Abstract

In recent years, using magnetic nanocomposites for controlled release of drugs and target-specific drug delivery has great potential in exploring a new method for Cancer chemotherapy. Nevertheless, the low loading rate of insoluble drugs greatly restricts their efficacy and clinical application. Here, an efficient magnetic nanostructure combining Fe3O4 nanoparticles and layered double hydroxide (LDH) was developed and used for tumor cell inhibition. LDH was first deposited on Fe3O4 nanoparticles (Fe3O4@LDH), curcumin (Cur) was then loaded and polydopamine (PDA) eventually formed a PDA-coating on Fe3O4@Cur-LDH via self-polymerization. The Fe3O4@Cur-LDH/PDA nanostructure showed a suitable nano-meter size, excellent magnetic property, and high drug loading rate (up to 38%). In vitro release results implied that Fe3O4@Cur-LDH/PDA nanostructure had good pH-responsive performance and excellent controlled-release behaviors due to the introduction of PDA. The cellular experiments demonstrated that Fe3O4@Cur-LDH/PDA nanostructure had good biocompatibility. In addition, Fe3O4@Cur-LDH/PDA entered into the cells mainly through endocytosis and had excellent inhibition on HepG2 cell viability in a concentration-dependent manner. Therefore, Fe3O4@Cur-LDH/PDA nanostructure has a prospective application in Cancer therapy as a controlled drug delivery system.

Keywords

Biomedical applications; Controlled drug delivery; Layered hydroxide; Magnetic nanocarrier; pH-responsive.

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