2. Academic Validation
  3. Inhibition of mitochondrial calcium uptake by Ru360 enhances the effect of 1800 MHz radio-frequency electromagnetic fields on DNA damage

Inhibition of mitochondrial calcium uptake by Ru360 enhances the effect of 1800 MHz radio-frequency electromagnetic fields on DNA damage

  • Ecotoxicol Environ Saf. 2023 Sep 14;264:115472. doi: 10.1016/j.ecoenv.2023.115472.
Chuan Sun 1,  Longtao Zhu 2,  Houbing Qin 3,  Huili Su 4,  Jing Zhang 4,  Sanying Wang 4,  Xiaogang Xu 4,  Zhenlei Zhao 4,  Genxiang Mao 5,  Jun Chen 6
Affiliations

Affiliations

  • 1 Zhejiang Provincial Key Lab of Geriatrics & Geriatrics Institute of Zhejiang Province, Department of Geriatrics, Zhejiang Hospital, Hangzhou, China. Electronic address: sun_chuan@aliyun.com.
  • 2 Bioelectromagnetics Laboratory, Zhejiang University School of Medicine, Hangzhou, China.
  • 3 Department of Respiratory Medicine, Children's Hospital of Nanjing Medical University, Nanjing, China.
  • 4 Zhejiang Provincial Key Lab of Geriatrics & Geriatrics Institute of Zhejiang Province, Department of Geriatrics, Zhejiang Hospital, Hangzhou, China.
  • 5 Zhejiang Provincial Key Lab of Geriatrics & Geriatrics Institute of Zhejiang Province, Department of Geriatrics, Zhejiang Hospital, Hangzhou, China. Electronic address: maogenxiang@163.com.
  • 6 Zhejiang Provincial Key Lab of Geriatrics & Geriatrics Institute of Zhejiang Province, Department of Geriatrics, Zhejiang Hospital, Hangzhou, China. Electronic address: zjdxcj@126.com.
PMID: 37716072 DOI: 10.1016/j.ecoenv.2023.115472
Abstract

Today, the existence of radio-frequency electromagnetic fields (RF-EMF) emitted from cell phones, wireless routers, base stations, and other sources are everywhere around our living environment, and the dose is increasing. RF-EMF have been reported to be cytotoxic and supposed to be a risk factor for various human diseases, thus, more attention is necessary. In recent years, interfere with mitochondrial calcium uptake by using mitochondrial calcium uniporter (MCU) inhibitor were suggested to be potential clinical treatment in mitochondrial calcium overload diseases, like neurodegeneration, ischemia/reperfusion injury, and Cancer, but whether this approach increases the health risk of RF-EMF exposure are unknown. To address our concern, we did a preliminary study to determine whether inhibition of MCU will increase the genotoxicity of RF-EMF exposure in cells, and found that short-time (15 min) exposure to 1800 MHz RF-EMF induced significant DNA damage and cell Apoptosis in mouse embryonic fibroblasts (MEFs) treated with Ruthenium 360 (Ru360), a specific inhibitor of MCU, but no significant effects on cell cycle, cell proliferation, or cell viability were observed. In conclusion, our results indicated that inhibiting MCU increases the genotoxicity of RF-EMF exposure, and more attention needs to be paid to the possible health impact of RF-EMF exposure under these treatments.

Keywords

Calcium; DNA damage; Mitochondria; Radio-frequency electromagnetic fields; Ruthenium 360.

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