2. Academic Validation
  3. Allopregnanolone targets nucleoprotein as a novel influenza virus inhibitor

Allopregnanolone targets nucleoprotein as a novel influenza virus inhibitor

  • Virol Sin. 2023 Sep 21:S1995-820X(23)00111-6. doi: 10.1016/j.virs.2023.09.003.
Meiyue Dong 1,  Yanyan Wang 2,  Ping Li 2,  Zinuo Chen 1,  Varada Anirudhan 3,  Qinghua Cui 4,  Lijun Rong 5,  Ruikun Du 6
Affiliations

Affiliations

  • 1 Innovative Institute of Chinese Medicine and Pharmacy, Shandong University of Traditional Chinese Medcine, Jinan, 250355, China.
  • 2 College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, 250355, China.
  • 3 Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, Chicago, 60612, USA.
  • 4 Innovative Institute of Chinese Medicine and Pharmacy, Shandong University of Traditional Chinese Medcine, Jinan, 250355, China; Qingdao Academy of Chinese Medical Sciences, Shandong University of Traditional Chinese Medicine, Qingdao, 266122, China. Electronic address: cuiqinghua@sdutcm.edu.cn.
  • 5 Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, Chicago, 60612, USA. Electronic address: lijun@uic.edu.
  • 6 Innovative Institute of Chinese Medicine and Pharmacy, Shandong University of Traditional Chinese Medcine, Jinan, 250355, China; Qingdao Academy of Chinese Medical Sciences, Shandong University of Traditional Chinese Medicine, Qingdao, 266122, China. Electronic address: ruikun@sdutcm.edu.cn.
PMID: 37741571 DOI: 10.1016/j.virs.2023.09.003
Abstract

Influenza A virus (IAV) poses a global public health concern and remains an imminent threat to human health. Emerging Antiviral resistance to the currently approved influenza drugs emphasizes the urgent need for new therapeutic entities against IAV. Allopregnanolone (ALLO) is a natural product that has been approved as an antidepressant drug. In the present study, we repurposed ALLO as a novel inhibitor against IAVs. Mechanistic studies demonstrated that ALLO inhibited virus replication by interfering with the nucleus translocation of viral nucleoprotein (NP). In addition, ALLO showed significant synergistic activity with compound 16, a hemagglutinin inhibitor of IAVs. In summary, we have identified ALLO as a novel Influenza Virus Inhibitor targeting NP, providing a promising candidate that deserves further investigation as a useful anti-influenza strategy in the future.

Keywords

Allopregnanolone; Antiviral; Influenza A virus (IAV); Nucleoprotein; Nucleus translocation.

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