2. Academic Validation
  3. Fraxetin inhibits proliferation and induces apoptosis of bladder cancer through the Akt pathway in vitro and in vivo

Fraxetin inhibits proliferation and induces apoptosis of bladder cancer through the Akt pathway in vitro and in vivo

  • J Biochem Mol Toxicol. 2023 Oct 23:e23556. doi: 10.1002/jbt.23556.
Mingfang Weng 1,  Zhen Deng 1,  Shuijing Huang 2,  Xiaowen Lin 3,  Na Xu 1,  Xinghui Sun 1,  Weizhen Wu 1,  Jun Lu 4,  Dong Wang 1 4
Affiliations

Affiliations

  • 1 Department of Urology, 900TH Hospital of Joint Logistics Support Force, Fujian Medical University, Fuzhou, China.
  • 2 Department of Neurosurgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
  • 3 Department of Vascular Surgery, Fujian Provincial People's Hospital, Fuzhou, China.
  • 4 Fujian Provincial Key Laboratory of Transplant Biology, Dongfang Hospital (900TH Hospital of Joint Logistics Support Force), Xiamen University, Fuzhou, China.
PMID: 37867445 DOI: 10.1002/jbt.23556
Abstract

Fraxetin, a natural compound extracted from the Chinese herb Cortex Fraxini, is reported to boast extensive antitumor properties in various cancers. However, whether fraxetin exhibited an Anticancer effect on bladder Cancer remains unknown. In this study, cell counting kit-8 was utilized to detect cell viability. Flow cytometry analysis was performed for cell Apoptosis analysis. Western blot analysis and Real-Time PCR were used to ascertain gene expression analysis. A mouse bladder Cancer xenograft model was established and subjected to fraxetin treatment. Fraxetin reduced the viability of bladder Cancer cells, induced Apoptosis in vitro, and inhibited the growth of bladder Cancer in vivo. Fraxetin inhibited the Akt pathway in J82 cells. In conclusion, the growth inhibitory properties of fraxetin against bladder Cancer may be mediated via an Akt inhibitory effect and cell Apoptosis promotion.

Keywords

Akt; apoptosis; bladder cancer; fraxetin; proliferation.

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