2. Academic Validation
  3. Ubiquitin-conjugating enzyme E2C (UBE2C) is a prognostic indicator for cholangiocarcinoma

Ubiquitin-conjugating enzyme E2C (UBE2C) is a prognostic indicator for cholangiocarcinoma

  • Eur J Med Res. 2023 Dec 15;28(1):593. doi: 10.1186/s40001-023-01575-9.
Khaa Hoo Ong 1 2 3,  Hong-Yue Lai 4,  Ding-Ping Sun 1,  Tzu-Ju Chen 2 5,  Steven Kuan-Hua Huang 6 7,  Yu-Feng Tian 8,  Chia-Lin Chou 2 8,  Yow-Ling Shiue 3 9,  Ti-Chun Chan 10 11,  Chien-Feng Li 9 10 11 12,  Yu-Hsuan Kuo 13 14 15
Affiliations

Affiliations

  • 1 Division of Gastroenterology & General Surgery, Department of Surgery, Chi Mei Medical Center, Tainan, 710, Taiwan.
  • 2 Department of Medical Technology, Chung Hwa University of Medical Technology, Tainan, 717, Taiwan.
  • 3 Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung, 804, Taiwan.
  • 4 Department of Pharmacology, School of Medicine, China Medical University, Taichung, 404333, Taiwan.
  • 5 Department of Clinical Pathology, Chi Mei Medical Center, Tainan, 710, Taiwan.
  • 6 Division of Urology, Department of Surgery, Chi Mei Medical Center, Tainan, 710, Taiwan.
  • 7 Department of Medical Science Industries, College of Health Sciences, Chang Jung Christian University, Tainan, 711, Taiwan.
  • 8 Division of Colon and Rectal Surgery, Department of Surgery, Chi Mei Medical Center, Tainan, 710, Taiwan.
  • 9 Institute of Precision Medicine, National Sun Yat-Sen University, Kaohsiung, 804, Taiwan.
  • 10 Department of Medical Research, Chi Mei Medical Center, Tainan, 710, Taiwan.
  • 11 National Institute of Cancer Research, National Health Research Institutes, Tainan, 704, Taiwan.
  • 12 Trans-Omic Laboratory for Precision Medicine, Chi Mei Medical Center, Tainan, 710, Taiwan.
  • 13 Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung, 804, Taiwan. beethovan@gmail.com.
  • 14 Division of Hematology and Oncology, Department of Internal Medicine, Chi-Mei Medical Center, Tainan, 71004, Taiwan. beethovan@gmail.com.
  • 15 College of Pharmacy and Science, Chia Nan University, Tainan, 71710, Taiwan. beethovan@gmail.com.
PMID: 38102624 DOI: 10.1186/s40001-023-01575-9
Abstract

Cholangiocarcinoma is the most common malignant bile duct tumor in Southeast Asia. The special location of cholangiocarcinoma leads to it being difficult to diagnose. Currently, the progress in clinical prognosis outcomes remains abysmal owing to the lack of definitive diagnostic criteria. Therefore, uncovering the potential markers for cholangiocarcinoma is a pressing issue. Ubiquitin-conjugating enzyme E2 C (UBE2C) is a critical ubiquitination enzyme; it is involved in the tumorigenesis of various malignancies and affects the patient's prognosis. However, there is currently no relevant literature to indicate whether UBE2C is related to the clinical survival outcome of cholangiocarcinoma patients. In this report, we mined the published cholangiocarcinoma transcriptome data set (GSE26566), compared it with the ubiquitination-associated gene (GO:0016567), and identified that UBE2C was highly expressed in cholangiocarcinoma tumor tissue. Moreover, high expression of UBE2C was markedly correlated with surgical margin, primary tumor, histological variants, and histological grade. More specifically, high expression of UBE2C was negatively associated with overall survival, disease-specific survival, local recurrence-free survival, and metastasis-free survival in patients with cholangiocarcinoma. Our findings demonstrate that UBE2C may provide a potential therapeutic marker and prognostic factor for cholangiocarcinoma patients.

Keywords

Cholangiocarcinoma; Prognosis; UBE2C; Ubiquitination.

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