1. Academic Validation
  2. Alginate oligosaccharide alleviates vascular aging by upregulating glutathione peroxidase 7

Alginate oligosaccharide alleviates vascular aging by upregulating glutathione peroxidase 7

  • J Nutr Biochem. 2024 Jan 10:109578. doi: 10.1016/j.jnutbio.2024.109578.
Shan Wang 1 Yao Yu 1 Jia Liu 1 Song Hu 1 Shujuan Shi 1 Wenjing Feng 1 Yongjun Mao 2
Affiliations

Affiliations

  • 1 Department of Geriatric Medicine, The Affiliated Hospital of Qingdao University, Qingdao, China.
  • 2 Department of Geriatric Medicine, The Affiliated Hospital of Qingdao University, Qingdao, China. Electronic address: maoyongjun@qduhospital.cn.
Abstract

Alginate oligosaccharide (AOS) may delay aging by decreasing oxidative stress, but the effects on vascular aging remain unclear. Here, we evaluate the effect of AOS on vascular aging and investigate the underlying mechanisms. Twenty-month-old rats acted as the natural aging model in vivo. Senescence of human aortic vascular smooth muscle cells (HA-VSMCs) was induced in vitro using angiotensin II (AngII). The aging rats and senescent cells were treated with AOS, followed by assessment of aging makers, oxidative stress, and aging-induced vascular remodeling. AOS treatment alleviated vascular aging and HA-VSMC senescence and decreased the levels of oxidative stress and vascular remodeling-associated indicators. AOS upregulated the expression of Glutathione Peroxidase 7 (GPX7) in aging rats and GPX7 depletion disrupted the geroprotective effect of AOS. AOS increased the nuclear translocation of nuclear factor erythroid-2-related factor (Nrf2) protein, which interacts with GPX7 protein to induce its expression. In conclusion, AOS alleviates vascular aging and HA-VSMC senescence and reduces aging-related vascular remodeling via the GPX7 antioxidant pathway, which may provide new avenues for treating aging-associated diseases.

Keywords

Glutathione peroxidase 7; aging; alginate oligosaccharide; oxidative stress; senescence; vasculature.

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