2. Academic Validation
  3. MAPK/NF-κB signaling mediates atrazine-induced cardiorenal syndrome and antagonism of lycopene

MAPK/NF-κB signaling mediates atrazine-induced cardiorenal syndrome and antagonism of lycopene

  • Sci Total Environ. 2024 Feb 16:171015. doi: 10.1016/j.scitotenv.2024.171015.
Fu-Wei Jiang 1,  Jian-Ying Guo 1,  Jia Lin 2,  Shi-Yong Zhu 3,  Xue-Yan Dai 4,  Muhammad Asmat Ullah Saleem 1,  Yi Zhao 5,  Jin-Long Li 6
Affiliations

Affiliations

  • 1 College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, PR China.
  • 2 College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, PR China; Hubei Key Laboratory of Animal Nutrition and Feed Science, Hubei Collaborative Innovation Center for Animal Nutrition and Feed Safety, Wuhan Polytechnic University, Wuhan 430023, PR China.
  • 3 College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, PR China; College of Animal Science and Veterinary Medicine, Qingdao Agricultural University, Qingdao 266109, PR China.
  • 4 College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, PR China; Jiangxi Provincial Key Laboratory for Animal Health, Institute of Animal Population Health, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, PR China.
  • 5 College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, PR China; Key Laboratory of the Provincial Education Department of Heilongjiang for Common Animal Disease Prevention and Treatment, Northeast Agricultural University, Harbin 150030, PR China; Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, Northeast Agricultural University, Harbin 150030, PR China. Electronic address: zhaoyi@neau.edu.cn.
  • 6 College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, PR China; Key Laboratory of the Provincial Education Department of Heilongjiang for Common Animal Disease Prevention and Treatment, Northeast Agricultural University, Harbin 150030, PR China; Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, Northeast Agricultural University, Harbin 150030, PR China. Electronic address: Jinlongli@neau.edu.cn.
PMID: 38369134 DOI: 10.1016/j.scitotenv.2024.171015
Abstract

Atrazine (ATZ) is the most prevalent herbicide that has been widely used in agriculture to control broadleaf weeds and improve crop yield and quality. The heavy use of ATZ has caused serious environmental pollution and toxicity to human health. Lycopene (LYC), is a carotenoid that exhibits numerous health benefits, such as prevention of cardiovascular diseases and nephropathy. However, it remains unclear that whether ATZ causes cardiorenal injury or even cardiorenal syndrome (CRS) and the beneficial role of LYC on it. To test this hypothesis, mice were treated with LYC and/or ATZ for 21 days by oral gavage. This study demonstrated that ATZ exposure caused cardiorenal morphological alterations, and several inflammatory cell infiltrations mediated by activating NF-κB signaling pathways. Interestingly, dysregulation of MAPK signaling pathways and MAPK phosphorylation caused by ATZ have been implicated in cardiorenal diseases. ATZ exposure up-regulated cardiac and renal injury associated biomarkers levels that suggested the occurrence of CRS. However, these all changes were reverted, and the phenomenon of CAR was disappeared by LYC co-treatment. Based on our findings, we postulated a novel mechanism to elucidate pesticide-induced CRS and indicated that LYC can be a preventive and therapeutic agent for treating CRS by targeting MAPK/NF-κB signaling pathways.

Keywords

Atrazine; Cardiorenal syndrome; Lycopene; MAPK; NF-κB.

Figures
Products
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z