2. Academic Validation
  3. Antidiabetic Properties of Caffeoylmalic Acid, a Bioactive Natural Compound Isolated from Urtica dioica

Antidiabetic Properties of Caffeoylmalic Acid, a Bioactive Natural Compound Isolated from Urtica dioica

  • Fitoterapia. 2024 Jul:176:106024. doi: 10.1016/j.fitote.2024.106024.
Gauhar Rehman 1,  Ilman Khan 1,  Abdur Rauf 2,  Umer Rashid 3,  Arshma Siddique 3,  Syed Muhammad Mukarram Shah 4,  Zuneera Akram 5,  Najla AlMasoud 6,  Taghrid S Alomar 6,  Zafar Ali Shah 7,  Giovanni Ribaudo 8
Affiliations

Affiliations

  • 1 Department of Zoology, Abdul Wali Khan University Mardan, Mardan, KPK, Pakistan.
  • 2 Department of Chemistry, University of Swabi, Anbar 23561, Khyber Pakhtunkhwa, Pakistan. Electronic address: abdurrauf@uoswabi.edu.pk.
  • 3 Department of Chemistry, COMSATS University Islamabad, Abbottabad Campus, Abbottabad 22060, Pakistan.
  • 4 Department of Pharmacy, University of Swabi, Swabi, KPK, Pakistan.
  • 5 Department of Pharmacology, Faculty of Pharmaceutical Sciences, Baqai Medical University, Karachi, Pakistan.
  • 6 Department of Chemistry, College of Science, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh, 11671, Saudi Arabia.
  • 7 Department of Chemistry, University of Swabi, Anbar 23561, Khyber Pakhtunkhwa, Pakistan.
  • 8 Department of Molecular and Translational Medicine, University of Brescia, Italy. Electronic address: giovanni.ribaudo@unibs.it.
PMID: 38763410 DOI: 10.1016/j.fitote.2024.106024
Abstract

The uncontrolled hyperglycemia that characterizes diabetes mellitus (DM) causes several complications in the organism. DM is among the major causes of deaths, and the limited efficacy of current treatments push the search for novel drug candidates, also among natural compounds. We focused our attention on caffeoylmalic acid, a phenolic derivative extracted from Urtica dioica, a plant investigated for its potential against type 2 DM. This compound was tested for its antidiabetic activity in vitro through a glucose uptake assay, in vivo in a mouse DM model and through molecular docking towards α-amylase and α-glucosidase. The effects on glucose blood level, liver Enzymes, Insulin and creatinine levels as well as on lipid and blood parameters, considered biochemical markers of diabetes, were also evaluated. The results showed an antidiabetic activity in vitro and in vivo, as the compound stimulates glucose absorbtion and reduces blood glucose levels. Moreover, it ameliorates lipid profile, liver and blood parameters, with moderate effect on Insulin secretion. Taken together, these findings pave the way for the compounds from this class of caffeoylmalic acid as potential antidiabetic compounds.

Keywords

Caffeoylmalic acid; Diabetes; Molecular docking; Urtica dioica.

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