2. Academic Validation
  3. Statin therapy associated Lactobacillus intestinalis attenuates pancreatic fibrosis through remodeling intestinal homeostasis

Statin therapy associated Lactobacillus intestinalis attenuates pancreatic fibrosis through remodeling intestinal homeostasis

  • NPJ Biofilms Microbiomes. 2025 Apr 15;11(1):59. doi: 10.1038/s41522-025-00695-w.
Yuhang Sui 1 2,  Tao Zhang 3,  Suwen Ou 2 4,  Guanqun Li 2 4,  Liwei Liu 2 5,  Tianqi Lu 2 4,  Can Zhang 2 4,  Yukai Cao 6,  Rui Bai 2 4,  Haoxin Zhou 7,  Xinbo Zhao 6,  Yue Yuan 6,  Gang Wang 8,  Hua Chen 4,  Rui Kong 2 4,  Bei Sun 9 10,  Le Li 11
Affiliations

Affiliations

  • 1 Department of Liver Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
  • 2 Key Laboratory of Hepatosplenic Surgery, Ministry of Education, Harbin, China.
  • 3 Department of Hepatobiliary and Pancreaticosplenic Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
  • 4 Department of Pancreatic and Biliary Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
  • 5 Department of Minimally Invasive Biliary Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
  • 6 Department of Cardiology, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
  • 7 Department of Emergency Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
  • 8 Department of Oncology Endoscopic Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
  • 9 Key Laboratory of Hepatosplenic Surgery, Ministry of Education, Harbin, China. sunbei70@hrbmu.edu.cn.
  • 10 Department of Pancreatic and Biliary Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China. sunbei70@hrbmu.edu.cn.
  • 11 Department of Pancreatic and Biliary Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China. lile@hrbmu.edu.cn.
PMID: 40234406 DOI: 10.1038/s41522-025-00695-w
Abstract

Chronic pancreatitis (CP) is characterized by irreversible fibrotic destruction and impaired pancreatic function. CP disrupts lipid metabolism and causes the imbalance of gut microbiota which in turn exacerbates pancreatic fibrosis. Statins alter gut microbiota and exert anti-inflammatory effects, but its role in CP has not been fully elucidated. Here, we found that statins-associated higher abundance of Lactobacillus intestinalis (L.intestinalis) maintained gut homeostasis that restrained bacteria translocation from gut to the pancreas, which eventually aggravated pancreatic fibrosis through inhibiting CD8+T cells-dependent immunity. Fecal microbiota transplantation (FMT) or L.intestinalis administration inhibited the infiltration of CD8+T cells and macrophages that delayed CP progression. L.intestinalis restrained the recruitment of M1 macrophages and limited the release of Ccl2/7 in the colon, which prevented epithelial damage and epithelial barrier dysfunction through blocking Ccl2/7-Ccr1 signaling. Our findings elucidate that the utilization of statin therapy or supplementation of L.intestinalis can be potential approach for the therapies of CP.

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