2. Academic Validation
  3. Novel Cyclic Peptides as Interleukin-23 Inhibitor for Treating Inflammatory Disorders

Novel Cyclic Peptides as Interleukin-23 Inhibitor for Treating Inflammatory Disorders

  • ACS Med Chem Lett. 2025 Mar 27;16(4):532-533. doi: 10.1021/acsmedchemlett.5c00135.
Qi-Long Hu 1,  Steven H Liang 1
Affiliations

Affiliation

  • 1 Department of Radiology and Imaging Sciences, Emory University, 1364 Clifton Road, Atlanta, Georgia 30322, United States.
PMID: 40236523 DOI: 10.1021/acsmedchemlett.5c00135
Abstract

This patent application illustrates a series of cyclic peptides inhibiting Interleukin-23 (IL-23), as represented by Formula I. These cyclic peptides exhibit significant therapeutic potential for treating diseases and disorders associated with IL-23 imbalance, with a particular focus on inflammatory bowel disease (IBD).

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