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  3. Reduced fungal protein acetylation mediates the antimicrobial activity of a rhizosphere bacterium against a phytopathogenic fungus

Reduced fungal protein acetylation mediates the antimicrobial activity of a rhizosphere bacterium against a phytopathogenic fungus

  • Nat Commun. 2025 Jul 1;16(1):5644. doi: 10.1038/s41467-025-60870-7.
Ying-Chao Zhang 1,  Xin Zhan 1 2,  Jun-Yu Chen 1 2,  Ding-Tian Yu 1 2,  Tao Zhang 3,  Huiming Zhang 1,  Cheng-Guo Duan 4 5
Affiliations

Affiliations

  • 1 State Key Laboratory of Plant Trait Design, Shanghai Center for Plant Stress Biology, CAS Center for Excellence in Molecular Plant Sciences, Chinese Academy of Sciences, Shanghai, China.
  • 2 University of the Chinese Academy of Sciences, Beijing, China.
  • 3 Xinjiang Institute of Ecology and Geography, Chinese Academy of Sciences, Urumqi, China.
  • 4 State Key Laboratory of Plant Trait Design, Shanghai Center for Plant Stress Biology, CAS Center for Excellence in Molecular Plant Sciences, Chinese Academy of Sciences, Shanghai, China. cgduan@cemps.ac.cn.
  • 5 University of the Chinese Academy of Sciences, Beijing, China. cgduan@cemps.ac.cn.
PMID: 40595600 DOI: 10.1038/s41467-025-60870-7
Abstract

Rhizosphere microbes can protect Plants from phytopathogens, but the molecular mechanisms are often poorly understood. Here, we report that a rhizosphere bacterium, Bacillus amyloliquefaciens strain TG1-2 displays antimicrobial activity against various phytopathogenic fungi and oomycetes, in a process that is mediated by the NatA acetyltransferase complex in the phytopathogenic fungus Verticillium dahliae. We show that acetylation of the molecular chaperone Hsp83 by NatA facilitates the formation of a co-chaperone complex Hsp83-Sti1-Hsp70 involved in protein quality control. Dysfunction of NatA or disruption of Hsp83 acetylation results in dissociation of the co-chaperon complex, increasing protein degradation and fungal Apoptosis. Notably, TG1-2 and its major antimicrobial compound surfactin induce a reduction in Hsp83 acetylation, enhancing protein degradation and fungal Apoptosis. Thus, our study provides insights into the mechanisms underlying the antimicrobial action of a rhizosphere strain against phytopathogenic fungi.

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