2. Academic Validation
  3. Rebaudioside D and M, the next-generation sugar substitutes, do not exacerbate metabolic dysfunction in high-fat diet mice

Rebaudioside D and M, the next-generation sugar substitutes, do not exacerbate metabolic dysfunction in high-fat diet mice

  • Food Chem X. 2025 Jun 19:29:102679. doi: 10.1016/j.fochx.2025.102679.
Sangyi Lim 1 2,  Min-Jung Park 1,  Ki-Nam Yoon 3,  Junhyeong Lee 1 2,  Merc Emil Matienzo 1 2,  Seong-Jin Hong 3,  Keon Kim 2 4,  Yeong-Bin Baek 5,  Chang-Min Lee 2 4,  Young-Min Kim 6,  Bu-Soo Park 7 8,  Dong-Il Kim 1 2
Affiliations

Affiliations

  • 1 Department of Veterinary Physiology, College of Veterinary Medicine, Chonnam National University, Gwangju 61186, Republic of Korea.
  • 2 College of Veterinary Medicine and BK21 FOUR Program, Chonnam National University, Gwangju 61186, Republic of Korea.
  • 3 Research Institute of Agricultural Science and Technology, Chonnam National University, Gwangju 61186, Republic of Korea.
  • 4 Department of Veterinary Internal Medicine, College of Veterinary Medicine, Chonnam National University, Gwangju 61186, Republic of Korea.
  • 5 Department of Veterinary Pathology, College of Veterinary Medicine, Chonnam National University, Gwangju 61186, Republic of Korea.
  • 6 Department of Food Science and Technology, Graduate School of Chonnam National University, Gwangju 61186, Republic of Korea.
  • 7 Department of Chemical & Biological Engineering, Korea University, Seoul 02841, Republic of Korea.
  • 8 Bio-convergence R&D Center, Samyang Corp., Seongnam-si, Gyeonggi-do 13488, Republic of Korea.
PMID: 40612770 DOI: 10.1016/j.fochx.2025.102679
Abstract

As concerns about sugar-sweetened beverages are increasing, interest in natural Sweeteners with zero calories is also growing. This study explores the health impacts of rebaudioside D and M, emerging sugar substitutes, compared to traditional alternatives and stevioside. In mouse models, we investigated the effects of rebaudioside D and M on obesity, liver health, thermogenic adipocytes, skeletal muscle, and gut microbiota. Results show no weight gain or exacerbation of obesity, no promotion of hepatic steatosis, no impairment of brown adipose tissue function and no changes in skeletal muscle metabolic proteins with either rebaudioside. Importantly, both of these sugar substitutes positively influence gut microbiota without adverse metabolic effects, suggesting their potential as safe sugar alternatives.

Keywords

Gut microbiota; Obesity; Rebaudioside D; Rebaudioside M; Sugar substitute.

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