2. Academic Validation
  3. Core-shell structured CeO2@ZIF-8 nanohybrids regulating the Ce(III)/Ce(IV) valence conversion to enhance ROS-scavenging capacity for periodontitis treatment

Core-shell structured CeO2@ZIF-8 nanohybrids regulating the Ce(III)/Ce(IV) valence conversion to enhance ROS-scavenging capacity for periodontitis treatment

  • Biomaterials. 2026 Feb:325:123588. doi: 10.1016/j.biomaterials.2025.123588.
Yameng Yu 1,  Xiwen Zhao 2,  Yufeng Zheng 3,  Dandan Xia 4,  Yunsong Liu 5
Affiliations

Affiliations

  • 1 Department of Dental Materials, Peking University School and Hospital of Stomatology, Beijing, 100081, China; National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, Beijing, 100081, China.
  • 2 National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, Beijing, 100081, China; Department of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing, 100081, China.
  • 3 School of Materials Science and Engineering, Peking University, Beijing, 100871, China. Electronic address: yfzheng@pku.edu.cn.
  • 4 Department of Dental Materials, Peking University School and Hospital of Stomatology, Beijing, 100081, China; National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, Beijing, 100081, China. Electronic address: dandanxia@pku.edu.cn.
  • 5 National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, Beijing, 100081, China; Department of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing, 100081, China. Electronic address: liuyunsong@hsc.pku.edu.cn.
PMID: 40759062 DOI: 10.1016/j.biomaterials.2025.123588
Abstract

Colonization of pathogenic microorganism is the initiating factor of periodontitis, inflammatory-induced imbalance of reductant-oxidant homeostasis is the leading cause of alveolar bone defects. Herein, core-shell structured nanohybrids with Antibacterial, antioxidative and osteogenic properties were constructed by in situ growth of ZIF-8 nanocrystals onto cerium oxide nanoparticles (CeO2@ZIF-8). The Ce3+/Ce4+ ratio can be manipulated via regulating the ZIF-8 shell thickness. The shell thickness increased with elevated concentration of Zn2+ that coordinated with organic linker in the synthesis process, leading to enhanced Ce3+/Ce4+ ratio in CeO2@ZIF-8, which further promoted its antioxidative enzyme mimetic activities as well as osteogenic property. In vitro, CeO2@ZIF-8 exhibited excellent Antibacterial activities, provided cellular protective effect under oxidative stress state, and facilitated osteogenic differentiation. In vivo, CeO2@ZIF-8 could alleviated Bacterial infection induced inflammation response and promoted alveolar bone regeneration. The underlying mechanism was explored via bioinformatic analysis, which indicated that CeO2@ZIF-8 promoted the expression of copper-zinc superoxide dismutase (SOD1) via upregulating oxidoreductase activity, so that to relive the oxidative stress and upregulate the expression of osteogenesis related genes and proteins. The above findings indicated that CeO2@ZIF-8 could simultaneously achieve bacteriostasis, ROS scavenging and osteogenesis, so that to completely fulfill the therapeutic demand in the treatment of periodontitis.

Keywords

Cerium oxide; Core-shell nanohybrids; Metal organic frameworks; Periodontitis treatment; Reactive oxygen species scavenging.

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