2. Academic Validation
  3. Targeting and reversing tumor acidic microenvironment with bacterial cellulose-based micelles to enhance immune infiltration

Targeting and reversing tumor acidic microenvironment with bacterial cellulose-based micelles to enhance immune infiltration

  • Int J Biol Macromol. 2025 Sep 10:147598. doi: 10.1016/j.ijbiomac.2025.147598.
Shuangjun Li 1,  Ruyue Shi 1,  Yankun Liu 1,  Mingcong Niu 1,  Zhicun Liu 1,  Zhongjuan Wang 1,  Jiwang Gao 1,  Hongda Cai 1,  Zhuyu Zhou 1,  Shengnan Li 1,  Xiuhua Zhao 2
Affiliations

Affiliations

  • 1 Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Harbin, 150040, PR China; College of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, Harbin, 150040, PR China; Engineering Research Center of Forest Bio-preparation, Ministry of Education, Northeast Forestry University, Harbin, 150040, PR China; Heilongjiang Provincial Key Laboratory of Ecological Utilization of Forestry-based Active Substances, Harbin, 150040, PR China.
  • 2 Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Harbin, 150040, PR China; College of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, Harbin, 150040, PR China; Engineering Research Center of Forest Bio-preparation, Ministry of Education, Northeast Forestry University, Harbin, 150040, PR China; Heilongjiang Provincial Key Laboratory of Ecological Utilization of Forestry-based Active Substances, Harbin, 150040, PR China. Electronic address: xiuhuazhao@nefu.edu.cn.
PMID: 40939806 DOI: 10.1016/j.ijbiomac.2025.147598
Abstract

Immune cells infiltrating tumors play a pivotal role in tumor progression regulation; however, their functionality is frequently suppressed by the acidic conditions of the tumor microenvironment (TME). Targeting and reversing tumor acidity holds significant potential for enhancing the efficacy of immunotherapy. Here, we present a proof-of-concept study on tumor acidity-reversal therapy mediated by Bacterial cellulose-targeted micelles to promote M2 macrophage repolarization to M1 macrophages and restore the anti-tumor function of T cells. Our strategy utilizes a Bacterial cellulose (BC) composite modified with folic acid (FA) and chrysin (BY), loaded with lactic acid-neutralizing chemotherapeutic vincristine (VCR) and Lactate Dehydrogenase Inhibitor GNE-140, to self-assemble into tumor-targeted nanoparticles. Post-treatment, FA-BC-BY@VCR@GNE-140 demonstrated notable efficacy in reversing tumor acidity, inducing tumor cell death, mitigating immunosuppression, and stimulating host adaptive immunity. This approach represents an innovative strategy for synergizing chemotherapy and immunotherapy to combat tumor progression.

Keywords

Bacterial cellulose; Immune infiltration; Micelles; Tumor acidic microenvironment.

Figures
Products
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z