1. Academic Validation
  2. Prevention of spontaneous tumours in female rats by fadrozole hydrochloride, an aromatase inhibitor

Prevention of spontaneous tumours in female rats by fadrozole hydrochloride, an aromatase inhibitor

  • Br J Cancer. 1995 Jul;72(1):72-5. doi: 10.1038/bjc.1995.279.
D E Gunson 1 R E Steele R Y Chau
Affiliations

Affiliation

  • 1 Division of Preclinical Safety, Ciba-Geigy Corporation, Summit, New Jersey 07901, USA.
Abstract

Mammary tumours are oestrogen dependent in female Sprague-Dawley rats and in a significant proportion of women, so pharmacological treatment to inhibit oestrogen production is a valuable therapeutic measure to prevent or slow the progression of disease. Here we show that a non-steroidal aromatase inhibitor, which competitively inhibits the conversion of androstenedione to oestrone, prevents the development of both benign and malignant spontaneous mammary neoplasms in female Sprague-Dawley ats. It also slows the spontaneous development of pituitary pars distalis adenomas in female rats, and reduces the incidence of spontaneous hepatocellular tumours in male and female rats.

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