1. Academic Validation
  2. Signaling via hetero-oligomeric complexes of type I and type II serine/threonine kinase receptors

Signaling via hetero-oligomeric complexes of type I and type II serine/threonine kinase receptors

  • Curr Opin Cell Biol. 1996 Apr;8(2):139-45. doi: 10.1016/s0955-0674(96)80058-5.
P ten Dijke 1 K Miyazono C H Heldin
Affiliations

Affiliation

  • 1 Ludwig Institute for Cancer Research, Box 595, Biomedical Center, Uppsala, S-751 24, Sweden.
Abstract

Members of the transforming growth factor-beta (TGF-beta) superfamily have been found to signal by inducing the formation of hetero-oligomeric complexes of different type I and type II serine/threonine kinase receptors. Recent data indicate that binding of TGF-beta to its constitutively active type II receptor recruits the type I receptor into the complex; the type I receptor is thereafter phosphorylated and activated, processes which are necessary and sufficient for most TGF-beta mediated responses. Recent genetic analyses of Drosophila also indicate a strict requirement for both type I and type II receptors in decapentaplegic signaling in vivo.

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