2. 重组蛋白
  3. Cytokines and Growth Factors
  4. Interferon & Receptors
  5. IFN-alpha
  6. IFN-alpha 13

IFN-alpha 13  (干扰素 α13)

重组蛋白定制服务

干扰素 α13 (IFNA13;IFN-α13) 由巨噬细胞产生，属于 α / β 干扰素 (IFN) 家族，这是一种由病毒感染诱导的细胞因子家族，主要参与细胞的抗病毒防御[1]。干扰素 (IFN) 最初被认为是一种“干扰”体外病毒复制的物质。IFN-α/β 及其相关分子被分为 I 型 IFN，其他干扰素则分为两种——II 型干扰素 (IFN-γ) 和 III 型干扰素 (IFN-λ)[2]。干扰素刺激两种酶的产生:一种蛋白激酶和一种低聚腺苷酸合成酶。干扰素 α (IFNa) 在各种癌症中显示出显著的生物活性，特别是血液系统恶性肿瘤，如毛细胞白血病和慢性骨髓性白血病[3]。
干扰素 α13 对泰勒氏病毒、蒙哥病毒和水疱性口炎病毒表现出酸稳定的抗病毒活性。首先，它是组成性转录，独立于病毒感染和干扰素调节因子 7 的诱导。其次，它包含 2 个 N-糖基化位点，而小鼠的干扰素 α 亚型要么包含 1 个 N-糖基化位点，要么不包含[4]。干扰素 α 在动物模型中有广泛的应用，人源干扰素 α13 蛋白的氨基酸序列与小鼠有很大的差异 (64.55%)。

IFN-alpha 13 (IFNA13; IFN-α13) is produced by the macrophages, belongs to the alpha/beta interferon (IFN) family, a family of cytokines induced by viral infection and are primarily involved in antiviral defense of the cells[1]. Interferon (IFN) is originally identified as a substance ‘interfering’ with viral replication in vitro. IFN-α/β and related molecules are classified as type I IFNs, as for the other two types of type II IFN (IFN-γ) and type III IFNs (IFN-λ), respectively[2]. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. Interferon alpha (IFNa) shows significant biological activity in various cancers, paticularly haematological malignancies such as hairy cell leukaemia and chronic myelogenous leukaemia[3].
IFN-alpha13 exhibits acid-stable antiviral activity against Theiler's virus, Mengo virus, and vesicular stomatitis virus. Firstly, it is transcribed constitutively, independent of viral infection and of interferon regulatory factor-7 induction. Secondly, it contains two N-glycosylation sites, in contrast to other murine IFN-alpha subtypes that contain either one or no N-glycosylation site[4]. As for a wildly use of IFN in animal model, the sequence of amino acids in IFNA13 protein of human is very different from mouse (64.55%).

目录号 产品名 / 同用名 种属 表达系统
目录号 产品名 作用方式 纯度
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z