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  3. Interferon & Receptors
  4. IFN-alpha
  5. IFN-alpha 13
  6. IFN-alpha 13/IFNA1 蛋白, Human

IFN-alpha 13/IFNA1 蛋白, Human

目录号: HY-P72796
COA 产品使用指南

IFN-alpha 13 (IFNA13) 属于 I 型干扰素家族,由巨噬细胞产生而具有抗病毒活性。重组人 IFN-alpha 13/IFNA1 蛋白含有 166 个氨基酸 (C24-D189),由 E. coli 细胞产生,不带标签。

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10 μg ¥1250 In-stock
50 μg ¥3250 In-stock
100 μg   询价  

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描述

IFN-alpha 13 (IFNA13), belongs to type I interferon family, is produced by macrophages with antiviral activities[1]. IFN-alpha 13/IFNA1 Protein, Human contains 166 a.a. (C24-D189), produced in E. coli cells with tag free.

研究背景

IFN-α 13 (IFNA13;IFN-α13) 由巨噬细胞产生,属于 α/β 干扰素 (IFN) 家族,这是病毒感染诱导的细胞因子家族,主要参与细胞的抗病毒防御 [1].干扰素(IFN)最初被认为是一种在体外“干扰”病毒复制的物质。IFN-α/β及相关分子被归类为I型干扰素,其他两类分别为II型干扰素(IFN-γ)和III型干扰素(IFN-λ)[2]
干扰素刺激两种酶的产生:蛋白激酶和寡腺苷酸合成酶。干扰素 α (IFNa) 在多种癌症中显示出显着的生物活性,特别是血液系统恶性肿瘤,例如毛细胞白血病和慢性粒细胞白血病[3]
IFN-α13 对多种癌症具有酸稳定性抗病毒活性泰勒病毒、门戈病毒和水泡性口炎病毒。首先,它是组成型转录,独立于病毒感染和干扰素调节因子7诱导。其次,它包含两个 N-糖基化位点,与包含一个或不包含一个 N-糖基化位点的其他鼠科 IFN-α 亚型不同[4]。至于IFN在动物模型中的广泛使用,人IFNA13蛋白的氨基酸序列与小鼠有很大差异(64.55%)

生物活性

The specific activity determined by an anti-viral assay is no less than 1.0 × 108 IU/mg.

种属

Human

表达系统

E. coli

标签

Tag Free

蛋白编号

P01562 (C24-E189, A137V)

基因 ID
蛋白结构
N-term
IFNA1 (C24-E189, A137V)
Accession # P01562
C-term
中文名
重组人 IFN-alpha 13/IFNA1 蛋白
同用名
Interferon alpha-1/13; IFN-alpha-1/13; LeIF D; IFNA1; IFNA13
氨基酸序列

CDLPETHSLDNRRTLMLLAQMSRISPSSCLMDRHDFGFPQEEFDGNQFQKAPAISVLHELIQQIFNLFTTKDSSAAWDEDLLDKFCTELYQQLNDLEACVMQEERVGETPLMNADSILAVKKYFRRITLYLTEKKYSPCAWEVVRAEIMRSLSLSTNLQERLRRKE

分子量

Approximately 19.5 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE.

性状

无菌粉末.

组分

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4, containing 4% mannitol and 1% HSA.

内毒素含量

<1 EU/μg; determined by LAL method.

复溶方法

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.

保存条件 & 期限

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

运输条件

Room temperature in continental US; may vary elsewhere.

文件资料
参考文献

IFN-alpha 13/IFNA1 Protein, Human 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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