1. 重组蛋白
  2. Immune Checkpoint Proteins
  3. Stimulatory Immune Checkpoint Molecules
  4. LIGHT

LIGHT (TNFSF14/CD258), a type II transmembrane glycoprotein, is a homologous to lymphotoxins, with inducible nature and the ability to compete with herpes simplex virus glycoprotein D for herpes virus entry mediator (HVEM). LIGHT is a tumor necrosis factor (TNF) superfamily ligand which regulates T cell immune responses by signaling through two primary functional receptors, the HVEM and the lymphotoxin beta receptor (LT-beta-R). LIGHT is expressed on activated T cells, NK cells, monocytes, granulocytes, and immature dendritic cells (DCs); HVEM is expressed on resting T cells, NK cells, monocytes, immature DCs, and endothelial cells; LT-beta-R is expressed on DCs, endothelial cells, and stromal cells but is not expressed on lymphocytes. LIGHT is also trapped by non-functional soluble decoy receptor 3 (DcR3), which is highly expressed in various human tumors, such as multiple myeloma and diffuse large B-cell lymphoma. As a co-stimulator of T cells, on engagement with LT-beta-R, LIGHT induces cytotoxicity against some human cancer cells, and promotes cytokine production and the release of the naive T cell-attracting chemokines in stromal cells, thus leading to the increased presence of lymphocytes in tissues. In addition, triggering of HVEM signals on T cells by LIGHT co-stimulates T cell proliferation and interferon IFN-gamma secretion in response to T cell receptor engagement, leading to enhanced T cell immunity. LIGHT has been in pre-clinical development for over a decade and shows promise as a modality of enhancing treatment approaches in the field of cancer immunotherapy.

目录号 产品名 / 同用名 种属 表达系统
  • HY-P73837A
    LIGHT/TNFSF14 Protein, Mouse (sf9, His, solution)

    重组小鼠 LIGHT/TNFSF14 蛋白 (sf9, His, solution)

    Tumor necrosis factor ligand superfamily member 14; TNFSF14; HVEM-L; LIGHT  

    Mouse Sf9 insect cells
    LIGHT蛋白 (CD258; TNFRSF14) 是由活化 T 细胞产生的 II 型跨膜蛋白,是 TNFRSF14/HVEM 配体,属于肿瘤坏死因子 (TNF) 家族。LIGHT 蛋白主要在脾脏中表达,具有膜结合型和可溶性型两种亚型。LIGHT蛋白可以作为肿瘤的免疫检查点分子,并刺激自然杀伤细胞产生干扰素 TFNγ,触发肿瘤凋亡信号。LIGHT 蛋白还参与 LTβR-NIK-p52 NF-κB 的显性通路促进炎症基因表达。此外,LIGHT 蛋白是激活淋巴样细胞的共刺激因子,对疱疹病毒感染有抑制作用。小鼠 LIGHT/TNFSF14 蛋白含有 239 个氨基酸和一个跨膜结构域 (38-58 a.a.)。重组小鼠 LIGHT/TNFSF14 蛋白 (sf9, His, solution) 是溶液形式的小鼠 LIGHT/TNFSF14 蛋白的胞外部分 (D72-V239),由 Sf9 昆虫细胞表达,具有 N 端 His 标记。
目录号 产品名 作用方式 纯度