2. 重组蛋白
  3. Cytokines and Growth Factors
  4. Chemokine & Receptors
  5. CC Chemokines
  6. MCP-3 Protein/CCL7

MCP-3 Protein/CCL7  (趋化因子 CCL7)

重组蛋白定制服务

CCL7，又称单核细胞趋化蛋白 3 (MCP3)，是一种小细胞因子。在人类基因组中，CCL7 由位于染色体 17q11.2-q12 上的CCL7 基因编码。由 99 个氨基酸组成，其中含有23个氨基酸的信号肽，而约 76个氨基酸的成熟蛋白是在信号肽裂解后分泌。CCL7 在多种细胞类型中表达，如基质细胞、角质形成细胞、气道平滑肌细胞、实质细胞、成纤维细胞和白细胞以及肿瘤细胞[1]。CCL7 一般是以单体形式存在，可以与多种受体结合，包括 CCR1、CCR2、CCR3、CCR5 和 CCR10来介导对免疫细胞类型的影响。CCL7 可以作为一种化学诱导剂，吸引各种白细胞，包括单核细胞和中性粒细胞。通过将白细胞募集到受感染的组织以介导免疫反应，也参与了单核细胞动员以及将单核细胞募集到炎症部位，以及通过增加细胞内 Ca2+ 通量来诱导中性粒细胞迁移到炎症部位。CCL7 参与抗菌、抗病毒和抗真菌免疫反应，以及与各种免疫疾病有关，如溃疡性结肠炎、多发性硬化症或非特应性和特应性哮喘。与此同时，CCL7 的表达可以激活抗肿瘤免疫反应[2]。

CCL7, also known as monocyte chemotactic protein 3 (MCP3), is a small cell factor. In the human genome, CCL7 is encoded by the CCL7 gene located on chromosome 17q11.2-q12. It consists of 99 amino acids, including a signal peptide of 23 amino acids, while a mature protein of approximately 76 amino acids is secreted upon signal peptide cleavage. CCL7 is expressed in a variety of cell types, such as stromal cells, keratin-forming cells, airway smooth muscle cells, parenchymal cells, fibroblasts and leukocytes, and tumor cells[1]. CCL7 is generally present as a monomer and can bind to a variety of receptors, including CCR1, CCR2, CCR3, CCR5 and CCR10 to mediate effects on immune cell types.CCL7 can act as a chemoattractant, attracting a variety of leukocytes, including monocytes and neutrophils. It mediates the immune response by recruiting leukocytes to infected tissues and is also involved in monocyte mobilization and recruitment of monocytes to sites of inflammation, as well as inducing neutrophil migration to sites of inflammation by increasing intracellular Ca2+ flux. CCL7 is involved in antibacterial, antiviral and antifungal immune responses, as well as being associated with various immune diseases such as ulcerative colitis, multiple sclerosis or non-atopic and atopic asthma. At the same time, CCL7 expression activates antitumor immune responses[2].

目录号 产品名 / 同用名 种属 表达系统
  • HY-P7242
    MCP-3/CCL7 Protein, Human

    重组人单核细胞趋化蛋白-3/CCL7

    rHuMCP-3/CCL7; C-C motif chemokine 7; MCP3; SCYA6; SCYA7

    		Human E. coli
    MCP-3/CCL7 Protein, Human 是一种 CC 趋化因子和引诱剂，可以与 CCR1、CCR2 和 CCR3 结合，介导抗病毒、抗菌、抗肿瘤等免疫反应。MCP-3/CCL7 Protein, Human (CHO) 是由 E.coil 表达的重组人 MCP-3/CCL7(Q24-L99)。
  • HY-P7240
    MCP-3/CCL7 Protein, Human (CHO)

    重组人单核细胞趋化蛋白-3/CCL7 (CHO)

    rHuMCP-3/CCL7; C-C motif chemokine 7; MCP3; SCYA6; SCYA7

    		Human CHO
    MCP-3/CCL7 Protein, Human (CHO) 是一种 CC 趋化因子和引诱剂，可以与 CCR1、CCR2 和 CCR3 结合，介导抗病毒、抗菌、抗肿瘤等免疫反应。MCP-3/CCL7 Protein, Human (CHO) 是由 CHO 表达的重组人 MCP-3/CCL7(Q24-L99)。
  • HY-P7243
    MCP-3/CCL7 Protein, Mouse

    重组小鼠MCP-3/CCL7

    rMuMCP-3/CCL7; C-C motif chemokine 7; MCP3; SCYA7

    		Mouse E. coli
    MCP-3/CCL7 Protein, Mouse 是一种 CC 趋化因子和引诱剂，可以与 CCR1、CCR2 和 CCR3 结合，介导抗病毒、抗菌、抗肿瘤等免疫反应。MCP-3/CCL7 Protein, Mouse 是由 E.coil 表达的重组鼠 MCP-3/CCL7(Q24-P97)。
  • HY-P7244
    MCP-3/CCL7 Protein, Rat

    重组大鼠MCP-3/CCL7

    rRtMCP-3/CCL7; C-C motif chemokine 7; MCP3; SCYA7

    		Rat E. coli
    MCP-3/CCL7 Protein, Rat 是一种 CC 趋化因子和引诱剂，可以与 CCR1、CCR2 和 CCR3 结合，介导抗病毒、抗菌、抗肿瘤等免疫反应。MCP-3/CCL7 Protein, Rat 是由 E.coil 表达的重组大鼠 MCP-3/CCL7(Q24-P97)。
目录号 产品名 作用方式 纯度
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