1. 重组蛋白
  2. Cytokines and Growth Factors
  3. TNF Superfamily
  4. TNF Superfamily Ligands
  5. TNF-β

TNF-β  (肿瘤坏死因子-β)

TNF-β (tumor necrosis factor β) 又称淋巴毒素-α (LT-α),是肿瘤坏死因子超家族的成员,是一种由淋巴细胞产生的细胞因子。TNF-β 激活 NF-κB 信号通路,诱导癌细胞增殖、侵袭[1][2]。TNF-β 上调转移相关基因的表达,促进上皮-间质转化,刺激自身表达[3]。TNF-β 介导多种炎症、免疫刺激和抗病毒反应。

TNF-β (tumor necrosis factor β) also called lymphotoxin-α (LT-α), a member of the tumor necrosis factor superfamily, is a cytokine produced by lymphocytes. TNF-β activates the NF-κB signaling pathway, inducing cancer cell proliferation, invasion[1][2]. TNF-β up-regulates genes connected with metastasis, promotes epithelial-to-mesenchymal-transition, stimulates its own expression[3]. TNF-β mediates a large variety of inflammatory, immunostimulatory, and antiviral responses.

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