4-1BB/TNFRSF9 蛋白, Mouse (HEK293, C-hFc)

The 4-1BB/TNFRSF9 protein (TNFSF9/4-1BBL receptor) sends critical signals that enhance the survival, cytotoxicity, and mitochondrial activity of CD8(+) T cells, thereby promoting immunity against viruses and tumors. Mainly a homodimer, it can exist in a monomeric state. 4-1BB/TNFRSF9 Protein, Mouse (HEK293, C-hFc) is the recombinant mouse-derived 4-1BB/TNFRSF9 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of 4-1BB/TNFRSF9 Protein, Mouse (HEK293, C-hFc) is 164 a.a., with molecular weight of approximately 58.72 kDa.

4-1BB/TNFRSF9 蛋白作为 TNFSF9/4-1BBL 的受体，在传递增强 CD8(+) T 细胞存活、细胞毒性和线粒体活性的信号方面发挥着关键作用，从而有助于增强对病毒和病毒的免疫力。肿瘤。它主要以同二聚体结构存在，也可能存在单体状态。与关键信号分子（包括 p56-LCK）的关联以及与 TRAF1、TRAF2 和 TRAF3 的相互作用，强调了其在介导促进免疫反应和调节功能所必需的细胞内途径中的重要性。

Measured by its ability to block 4-1BBL-induced IL-2 secretion by mouse CTLL-2 cells. The ED₅₀ for this effect is 0.603 μg/mL in the presence of 10 μg/mL anti-CD3, corresponding to a specific activity is 1.66×10^3 U/mg.

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  Measured by its ability to block 4-1BBL-induced IL-2 secretion by mouse CTLL-2 cells. The ED₅₀ for this effect is 0.603 μg/mL in the presence of 10 μg/mL anti-CD3, corresponding to a specific activity is 1.66×10³ U/mg.

Mouse

HEK293

C-hFc

P20334 (V24-L187)

21942  [NCBI]

VQNSCDNCQPGTFCRKYNPVCKSCPPSTFSSIGGQPNCNICRVCAGYFRFKKFCSSTHNAECECIEGFHCLGPQCTRCEKDCRPGQELTKQGCKTCSLGTFNDQNGTGVCRPWTNCSLDGRSVLKTGTTEKDVVCGPPVVSFSPSTTISVTPEGGPGGHSLQVL

approximately 58.72 kDa

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of 20 mM MES, 150 mM NaCl, pH 5.5.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.