ABAT 蛋白, Human (His-SUMO)

ABAT, Human (His-SUMO) is a γ-Aminobutyric acid transaminase which is responsible for GABA metabolism. ABAT, Human is implicated in mitochondrial nucleoside metabolism, respiratory capacity, membrane potential, and mitochondrial DNA maintenance.

GABA 转氨酶 (ABAT) 是负责 GABA 代谢的蛋白质。ABAT 介导 GABA 代谢途径，这是三羧酸循环 (TCAC) 中的一种旁路机制，产生琥珀酸和 NADH。γ-氨基丁酸 (GABA) 通常被描述为一种抑制性神经递质，在神经实质中浓度很高，在中枢神经系统中具有多种作用。ABAT 表达升高导致 GABA 分解代谢增加，肿瘤细胞增殖减少。在哺乳动物中，ABAT 表达减少与原发性透明细胞肾癌、乳腺癌和骨髓增生异常综合征的肿瘤发生有关。ABAT 已被证明与线粒体核苷代谢、呼吸能力、膜电位和线粒体 DNA 维持有关^[1]。

Human

E. coli

N-10*His;N-SUMO

P80404 (S29-K500)

18  [NCBI]

SQAAAKVDVEFDYDGPLMKTEVPGPRSQELMKQLNIIQNAEAVHFFCNYEESRGNYLVDVDGNRMLDLYSQISSVPIGYSHPALLKLIQQPQNASMFVNRPALGILPPENFVEKLRQSLLSVAPKGMSQLITMACGSCSNENALKTIFMWYRSKERGQRGFSQEELETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYPLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRDIARKHGCAFLVDEVQTGGGCTGKFWAHEHWGLDDPADVMTFSKKMMTGGFFHKEEFRPNAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLNNAAHAGKALLTGLLDLQARYPQFISRVRGRGTFCSFDTPDDSIRNKLILIARNKGVVLGGCGDKSIRFRPTLVFRDHHAHLFLNIFSDILADFK

Approximately 73.3 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.

• [1]. Martirosian V, et, al. Medulloblastoma uses GABA transaminase to survive in the cerebrospinal fluid microenvironment and promote leptomeningeal dissemination. Cell Rep. 2021 Jun 29;35(13):109302.  [Content Brief]