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  4. ABCC1 蛋白, Human (His)

ABCC1 蛋白, Human (His)

目录号: HY-P72069
产品使用指南

ABCC1, Human (His) 是一种多任务 ATP 结合盒 (ABC) 转运蛋白。 ABCC1, Human 在炎症和其他免疫疾病、年龄相关性黄斑变性、心血管疾病和某些神经系统疾病以及肿瘤进展中发挥作用。

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规格 是否有货
50 μg   询价  
100 μg   询价  

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描述

ABCC1, Human (His) is a multitasking ATP-binding cassette (ABC) transporter. ABCC1, Human plays a part in inflammatory and other immunological diseases, age-related macular degeneration, cardiovascular disease, and certain neurological disorders as well as tumor progression.
研究背景

多药耐药蛋白 1（MRP1、ABCC1）是一种多任务 ATP 结合盒 (ABC) 转运蛋白，可能影响许多人类疾病的病因和进展。MRP1 转运多种治疗药物以及多种生理底物，并可能在多种癌症（包括肺癌、乳腺癌和前列腺癌以及儿童神经母细胞瘤）的耐药性发展中发挥作用。越来越多的证据表明，MRP1 是参与神经母细胞瘤多药耐药性发展的 MYCN 靶基因。MRP1 还在炎症和其他免疫性疾病、年龄相关性黄斑变性、心血管疾病和某些神经系统疾病以及肿瘤进展中发挥作用[1][2] 。
种属

Human
表达系统

E. coli
标签

N-6*His
蛋白编号

P33527 (V1248-V1531)
基因 ID
蛋白结构
N-term
6*His
ABCC1 (V1248-V1531)
Accession # P33527
C-term
同用名
ABC 29; ABC29; ABCC 1; ABCC; Abcc1; ATP binding cassette sub family C CFTR/MRP; member 1; ATP binding cassette sub-family C member 1; ATP binding cassette subfamily C member 1; ATP binding cassette transporter variant ABCC1delta ex13; ATP binding cassette transporter variant ABCC1delta ex13&14; ATP binding cassette transporter variant ABCC1delta ex25; ATP binding cassette transporter variant ABCC1delta ex25&26; ATP binding cassette, sub-family C CFTR/MRP; , member 1; ATP-binding cassette sub-family C member 1; DKFZp686N04233; DKFZp781G125; GS X; GSX; Leukotriene C4; transporter; LTC4 transporter; MRP 1; MRP; MRP1; MRP1_HUMAN; Multidrug resistance associated protein 1; Multidrug resistance protein; Multidrug resistance-associated protein 1; Multiple drug resistance associated protein; Multiple drug resistance protein 1
氨基酸序列

VRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYSMAkDaGLV

分子量

Approximately 35.9 kDa
纯度

Greater than 90% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)
参考文献

ABCC1 Protein, Human (His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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