1. 重组蛋白
  2. Enzymes & Regulators
  3. Hydrolases (EC 3) Angiotensin-converting Enzymes
  4. Angiotensin-Converting Enzyme 2 (ACE2)
  5. ACE2 蛋白, Human (HEK293, hFc, solution)

ACE2 蛋白, Human (HEK293, hFc, solution)

目录号: HY-P7442
COA 产品使用指南

ACE2 蛋白, Human, (HEK293, Fc, solution)是一种SARS-CoV-2受体。Angiotensin-Converting Enzyme 2能有效地将血管紧张素II水解成血管紧张素。这种作用的结果是ACE2参与肾素-血管紧张素系统。

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规格 价格 是否有货 数量
10 μg ¥1900 In-stock
50 μg ¥5700 In-stock
100 μg   询价  
250 μg   询价  

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描述

ACE2 Protein, Human, (HEK293, Fc, solution) is a SARS-CoV-2 receptor. Angiotensin-Converting Enzyme 2 efficiently hydrolyses the potent vasoconstrictor angiotensin II to angiotensin. It is a consequence of this action that ACE2 participates in the renin-angiotensin system.

研究背景

Angiotensin-Converting Enzyme 2 (ACE2) is a type I integral membrane protein which functions as a carboxypeptidase, cleaving a single hydrophobic/basic residue from the C-terminus of its substrates. ACE2 efficiently hydrolyses the potent vasoconstrictor angiotensin II to angiotensin. It is a consequence of this action that ACE2 participates in the renin-angiotensin system. However, ACE2 also hydrolyses dynorphin A (1–13), apelin-13 and des-Arg9 bradykinin. The role of ACE2 in these peptide systems has yet to be revealed. A physiological role for ACE2 has been implicated in hypertension, cardiac function, heart function and diabetes, and as a receptor of the severe acute respiratory syndrome coronavirus. This paper reviews the biochemistry of ACE2 and discusses key findings such as the elucidation of crystal structures for ACE2 and testicular ACE and the development of ACE2 inhibitors that have now provided a basis for future research on this enzyme.

生物活性

Binding ability is measured by functional ELISA, 10 μg/mL (100 µL/well) of immoblized recombinant human Angiotensin-Converting Enzyme 2, C-Fc can bind to S Proetin RBD-SD1, C-mFc. The ED50 of recombinant S Protein RBD-SD1, C-mFc is 15.5 ng/mL.

种属

Human

表达系统

HEK293

标签

Tag Free

蛋白编号

Q9BYF1 (Q18-S740)

基因 ID

59272  [NCBI]

中文名
重组人血管紧张素转换酶 2,C-Fc (HEK293 表达)
同用名
Angiotensin-Converting Enzyme 2; ACE-Related Carboxypeptidase; Angiotensin-Converting Enzyme Homolog; ACEH; Metalloprotease MPROT15; ACE2
氨基酸序列

QSTIEEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQQNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMANSLDYNERLWAWESWRSEVGKQLRPLYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAYPSYISPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGNVQKAVCHPTAWDLGKGDFRILMCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANEGFHEAVGEIMSLSAATPKHLKSIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWWEMKREIVGVVEPVPHDETYCDPASLFHVSNDYSFIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDISNSTEAGQKLFNMLRLGKSEPWTLALENVVGAKNMNVRPLLNYFEPLFTWLKDQNKNSFVGWSTDWSPYADQSIKVRISLKSALGDKAYEWNDNEMYLFRSSVAYAMRQYFLKVKNQMILFGEEDVRVANLKPRISFNFFVTAPKNVSDIIPRTEVEKAIRMSRSRINDAFRLNDNSLEFLGIQPTLGPPNQPPVS

分子量

110-140 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE.

性状

Solution.

组分

Supplied as a 0.2 μm filter solution of 20 mM Tris-HCl, 1 mM ZnCl2, 10% Glycerol, pH 7.4.

内毒素含量

<1 EU/μg, determined by LAL method.

保存条件 & 期限

Stored at -80°C. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

运输条件

Shipping with dry ice.

文件资料
参考文献
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  • 重组蛋白稀释计算器

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific active calculator equation

Specific Active (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Active (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
ACE2 Protein, Human (HEK293, hFc, solution)
目录号:
HY-P7442
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