2. 重组蛋白
  3. Enzymes & Regulators
  4. Oxidoreductases (EC 1)
  5. ADH5 蛋白, Human (GST)

ADH5 蛋白, Human (GST)

目录号: HY-P701930
产品使用指南

ADH5 蛋白催化长链伯醇和 S-（羟甲基）谷胱甘肽的氧化。它还氧化长链欧米茄羟基脂肪酸，产生中间醛和最终产品。然而，它对氧化乙醇无效。ADH5 对于清除细胞毒性甲醛至关重要，甲醛会导致 DNA 损伤。ADH5 蛋白, Human (GST) 是重组的 ADH5 蛋白，由 E. coli 表达，带有 N-GST 标签。ADH5 蛋白, Human (GST) 全长 374 个氨基酸。

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描述

The ADH5 protein catalyzes the oxidation of long-chain primary alcohols and S-(hydroxymethyl) glutathione. It also oxidizes long-chain omega-hydroxy fatty acids, producing intermediate aldehydes and end products. However, it is ineffective in oxidizing ethanol. ADH5 is crucial for clearing cytotoxic formaldehyde, which causes DNA damage. ADH5 Protein, Human (GST) is the recombinant human-derived ADH5 protein, expressed by E. coli , with N-GST labeled tag. The total length of ADH5 Protein, Human (GST) is 374 a.a., .
研究背景

ADH5 是一种 III 类乙醇脱氢酶，通过催化长链伯醇和 S-（羟甲基）谷胱甘肽的氧化，在细胞解毒过程中发挥关键作用。此外，ADH5 还参与长链 omega-羟基脂肪酸（例如 20-羟基二十碳四烯酸 (20-HETE)）的氧化，产生中间体醛、20-氧代花生四烯酸和最终产物二羧酸（ 5Z,8Z,11Z,14Z)-二十碳四烯二酸酯。尽管 ADH5 被归类为乙醇脱氢酶，但其氧化乙醇的效率较低。值得注意的是，ADH5 对于细胞防御甲醛（一种细胞毒性和致癌代谢物）至关重要，有助于清除这种物质并防止潜在的 DNA 损伤。
种属

Human
表达系统

E. coli
标签

N-GST
蛋白编号

P11766 (M1-I374)
基因 ID

128
蛋白结构
N-term
GST
ADH5 (M1-I374)
Accession # P11766
C-term
同用名
ADH5; Alcohol dehydrogenase class-3; Alcohol dehydrogenase 5; Alcohol dehydrogenase class chi chain; Alcohol dehydrogenase class-III; Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH; GSH-FDH; S-(hydroxymethyl)glutathione dehydrogenase
纯度

Greater than 90% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

ADH5 Protein, Human (GST) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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