Adiponectin/Acrp30 蛋白, Mouse (HEK293, Fc)

Adiponectin/Acrp30 Protein is a protein hormone and adipokine, the most abundant peptide secreted by adipocytes, which is involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Adiponectin plays a inportant role in obesity-related diseases, insulin resistance/type 2 diabetes and cardiovascular disease. Adiponectin/Acrp30 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived Adiponectin/Acrp30 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Adiponectin/Acrp30 Protein, Mouse (HEK293, Fc) is 230 a.a., with molecular weight of 52-70 kDa.

Adiponectin 是一种蛋白质激素和脂肪因子，参与脂肪代谢和胰岛素敏感性的控制，具有直接的抗糖尿病、抗动脉粥样硬化和抗炎活性。Adiponectin 在肝脏、骨骼肌和脉管系统中具有直接作用。Adiponectin 以多聚化产生的不同分子量形式存在于循环中。Adiponectin 主要通过调节脂肪酸氧化和抑制肝葡萄糖产生来增强胰岛素敏感性，也可以促进大脑的突触和记忆功能。Adiponectin 刺激肝脏和骨骼肌中的 AMPK 磷酸化和激活，增强葡萄糖利用率和脂肪酸燃烧。同时它通过负调节 TNF-α 在肝脏和巨噬细胞等多种组织中的表达来拮抗 TNF-α，并抵消其作用。Adiponectin 通过 cAMP 依赖性途径抑制内皮 NF-kappa-B 信号传导。Adiponectin 可能通过结合和隔离具有不同结合亲和力的各种生长因子，在细胞生长、血管生成和组织重塑中发挥作用，具体取决于复合物的类型、LMW、MMW 或 HMW^{[1][2][3][4][5][6][7]}。

Mouse

HEK293

C-hFc

Q60994 (E18-N247)

11450  [NCBI]

EDDVTTTEELAPALVPPPKGTCAGWMAGIPGHPGHNGTPGRDGRDGTPGEKGEKGDAGLLGPKGETGDVGMTGAEGPRGFPGTPGRKGEPGEAAYVYRSAFSVGLETRVTVPNVPIRFTKIFYNQQNHYDGSTGKFYCNIPGLYYFSYHITVYMKDVKVSLFKKDKAVLFTYDQYQEKNVDQASGSVLLHLEVGDQVWLQVYGDGDHNGLYADNVNDSTFTGFLLYHDTN

52-70 kDa

Greater than 95% as determined by Tris-Bis PAGE.

无菌粉末.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Normally 8% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.