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  3. AE-binding 蛋白 1/Aebp1 蛋白, Mouse (His-SUMO)

AE-binding 蛋白 1/Aebp1 蛋白, Mouse (His-SUMO)

目录号: HY-P71566
COA 产品使用指南

AE-binding 蛋白 1/Aebp1 蛋白, Mouse (His-SUMO) 在调节脂肪生成和巨噬细胞的促炎过程中发挥关键作用,包括巨噬细胞胆固醇稳态、泡沫细胞形成和动脉粥样硬化的发展。

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规格 价格 是否有货 数量
20 μg ¥3600 In-stock
50 μg ¥7900 In-stock
100 μg   询价  

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描述

AE-binding protein 1/Aebp1 Protein, Mouse (His-SUMO) plays a critical role in regulating adipogenesis, and the proinflammation process in macrophages, including macrophage cholesterol homeostasis, foam cell formation and the development of atherosclerosis[1][2].

研究背景

AEBP1 作为转录抑制因子,通过 PPARgamma1 和 LXRalpha 下调来阻碍巨噬细胞胆固醇流出,促进泡沫细胞形成[1]
沉默AEBP1可显着抑制GC细胞的增殖、迁移、侵袭、转移和上皮间质转化。此外,我们还证明,GC 细胞中 AEBP1 的敲低可通过阻碍 IκBα[2] 的降解来抑制 NF-κB 通路。

种属

Mouse

表达系统

E. coli

标签

N-His;N-SUMO

蛋白编号

Q640N1 (26Q-370P)

基因 ID

11568  [NCBI]

蛋白结构
N-term
6*His-SUMO
Aebp1 (26Q-370P)
Accession # Q640N1
C-term
同用名
Aebp1; Aclp; Adipocyte enhancer-binding protein 1; AE-binding protein 1; Aortic carboxypeptidase-like protein
氨基酸序列

QTVLTDDEIEEFLEGFLSELETQSPPREDDVEVQPLPEPTQRPRKSKAGGKQRADVEVPPEKNKDKEKKGKKDKGPKATKPLEGSTRPTKKPKEKPPKATKKPKEKPPKATKKPKEKPPKATKKPKEKPPKATKRPSAGKKFSTVAPLETLDRLLPSPSNPSAQELPQKRDTPFPNAWQGQGEETQVEAKQPRPEPEEETEMPTLDYNDQIEKEDYEDFEYIRRQKQPRPTPSRRRLWPERPEEKTEEPEERKEVEPPLKPLLPPDYGDSYVIPNYDDLDYYFPHPPPQKPDVGQEVDEEKEEMKKPKKEGSSPKEDTEDKWTVEKNKDHKGPRKGEELEEEWAP

分子量

Approximately 70 kDa.The reducing (R) protein migrat es as 70 kDa in SDS-PAGE may be due to relative charge.

纯度

Greater than 90% as determined by reducing SDS-PAGE.

性状

无菌粉末.

组分

Lyophilized after extensive dialysis against solution in Tris-based buffer, 50% glycerol.

内毒素含量

<1 EU/μg, determined by LAL method.

复溶方法

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.

保存条件 & 期限

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

运输条件

Room temperature in continental US; may vary elsewhere.

文件资料
参考文献

AE-binding protein 1/Aebp1 Protein, Mouse (His-SUMO) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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AE-binding protein 1/Aebp1 Protein, Mouse (His-SUMO)
目录号:
HY-P71566
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