AGER 蛋白, Mouse (HEK293, His)

AGER proteins have multiple activities, including binding to S100 proteins, advanced glycation end products, and heparin. It is involved in cellular responses to amyloid, regulation of synaptic potentiation, and cytokine production. AGER Protein, Mouse (HEK293, His) is the recombinant mouse-derived AGER protein, expressed by HEK293 , with C-His labeled tag. The total length of AGER Protein, Mouse (HEK293, His) is 319 a.a., with molecular weight of ~50 kDa.

AGER 基因编码的蛋白质具有 S100 蛋白结合活性、高级糖基化终产物结合活性和肝素结合活性。AGER 参与多种过程，包括细胞对 β 淀粉样蛋白的反应、长期突触增强的负调节以及细胞因子产生的正调节，其在与诱导正趋化性、晚期糖基化末端的负调节相关的通路上游或内部发挥作用。产物受体活性，并对大分子代谢过程进行正向调节。AGER 主要位于细胞外空间和质膜，在消化系统、大脑、泌尿生殖系统、血淋巴系统、腺体和肺等多种结构中表达。AGER 的人类直系同源物（被称为高级糖基化终产物特异性受体）与多种疾病有关，包括自身免疫性疾病、心血管系统疾病、囊性纤维化、肾衰竭和狼疮性肾炎，在多种生理和病理环境中发挥着至关重要的作用。值得注意的是，其表达在成人肺部尤其丰富。

Immobilized Recombinant Mouse AGER Protein at 20 μg/mL (100 μL/well) can bind Biotinylated Recombinant Human HMGB1 Protein. The ED₅₀ for this effect is 0.6233-1.298 μg/mL.

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  Immobilized Recombinant Mouse AGER Protein at 20 μg/mL (100 μl/well) can bind Biotinylated Recombinant Human HMGB1 Protein. The ED₅₀ for this effect is 0.6233 μg/mL.

Mouse

HEK293

C-His

NP_031451.2 (Q24-A342)

11596  [NCBI]

QNITARIGEPLVLSCKGAPKKPPQQLEWKLNTGRTEAWKVLSPQGGPWDSVARILPNGSLLLPATGIVDEGTFRCRATNRRGKEVKSNYRVRVYQIPGKPEIVDPASELTASVPNKVGTCVSEGSYPAGTLSWHLDGKLLIPDGKETLVKEETRRHPETGLFTLRSELTVIPTQGGTHPTFSCSFSLGLPRRRPLNTAPIQLRVREPGPPEGIQLLVEPEGGIVAPGGTVTLTCAISAQPPPQVHWIKDGAPLPLAPSPVLLLPEVGHEDEGTYSCVATHPSHGPQESPPVSIRVTETGDEGPAEGSVGESGLGTLALA

Approximately 50 kDa

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.