AHSP 蛋白, Human

AHSP protein, a chaperone in erythroid cell development, safeguards alpha-hemoglobin, preventing harmful aggregation and precipitation. Crucial for alpha-hemoglobin stability, it modulates conditions linked to alpha-hemoglobin excess, like beta-thalassemia. AHSP forms a selective heterodimer with free alpha-hemoglobin, not binding to beta-hemoglobin or alpha(2)beta(2) hemoglobin A. This interaction prevents detrimental interactions, ensuring the proper hemoglobin component balance in erythropoiesis. AHSP Protein, Human is the recombinant human-derived AHSP protein, expressed by E. coli, with tag free. The total length of AHSP Protein, Human is 102 a.a., with molecular weight of ~12 KDa.

AHSP 蛋白在正常红细胞发育过程中充当伴侣，通过防止 α-血红蛋白沉淀来保护其免受有害聚集。这种保护功能对于维持游离α-血红蛋白的稳定性至关重要，并且对于调节与过量α-血红蛋白相关的病理状况（例如β-地中海贫血）特别相关。AHSP 作为单体存在，并与游离 α-血红蛋白形成特定的异二聚体复合物，由于它不与 β-血红蛋白或 α(2)β(2) 血红蛋白 A 复合物结合，因此具有选择性。这种相互作用强调了 AHSP 在红细胞生成过程中防止有害相互作用和维持血红蛋白成分适当平衡的作用。

Human

E. coli

Tag Free

Q9NZD4 (M1-S102)

51327  [NCBI]

MALLKANKDLISAGLKEFSVLLNQQVFNDPLVSEEDMVTVVEDWMNFYINYYRQQVTGEPQERDKALQELRQELNTLANPFLAKYRDFLKSHELPSHPPPSS

Approximately 12 kDa

Greater than 95% as determined by reducing SDS-PAGE

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.