AKT3 蛋白, Human (sf9, GST)

The AKT3 protein, like AKT1 and AKT2, is an important member of the AKT kinase family and plays a central role in a variety of cellular processes, including metabolism, proliferation, survival, growth, and angiogenesis. AKT3 has more than 100 reported targets and coordinates complex signaling pathways that control glucose uptake, regulate glycogen storage, and influence neurogenesis. AKT3 Protein, Human (sf9, GST) is the recombinant human-derived AKT3 protein, expressed by Sf9 insect cells , with N-GST labeled tag. The total length of AKT3 Protein, Human (sf9, GST) is 479 a.a., with molecular weight of ~81 kDa.

AKT2 是 AKT 激酶家族的重要成员，与 AKT1 和 AKT3 一起协调着无数的细胞过程，包括代谢、增殖、细胞存活、生长和血管生成。AKT2 通过众多下游底物的磷酸化来发挥作用，影响 100 多个已报道的靶标，表现出显着的功能多样性。它通过促进 SLC2A4/GLUT4 易位来控制胰岛素诱导的葡萄糖摄取，并复杂地调节胰岛素信号传导通路。此外，AKT2 调节糖原储存，抑制 GSK3 激酶活性，并在 AKT-mTOR 信号通路中发挥关键作用，影响神经发生和细胞迁移动力学。AKT2 参与磷酸化 FOXO 因子、CREB1 和与代谢相关的多个靶标，强调了其在细胞稳态中的关键地位。值得注意的是，AKT2 表现出同工型特异性功能，在调节葡萄糖摄取和参与骨骼肌分化等复杂过程中发挥着重要作用。最近对 PITX2 和 ANKRD2 等特定底物的鉴定进一步描述了 AKT2 微妙而复杂的细胞调节作用。

No Kinase Activity.

Human

Sf9 insect cells

N-GST

Q9Y243 (M1-E479)

10000  [NCBI]

Approximately 81 kDa

Greater than 90% as determined by reducing SDS-PAGE

溶液.

Supplied as sterile 50 mM Tris, 100 mM NaCl, 20% Glycerol, pH 8.0.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.