Allergin-1 蛋白, Mouse (HEK293, Fc)

Allergin-1 protein, an immunoglobulin-like receptor, inhibits mast cell degranulation and suppresses hypersensitivity reactions. It interacts with tyrosine-phosphorylated proteins, such as PTPN6, PTPN11, and INPP5D, to fine-tune mast cell responses. Allergin-1 plays a pivotal role in regulating allergic reactions and hypersensitivity responses. Allergin-1 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived Allergin-1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Allergin-1 Protein, Mouse (HEK293, Fc) is 150 a.a., with molecular weight of 55-80 KDa.

Allergin-1 蛋白是一种免疫球蛋白样受体，在肥大细胞的脱颗粒过程中发挥抑制作用。作为负调节因子，它在减轻 IgE 介导的肥大细胞激活和抑制 I 型速发型超敏反应方面发挥着至关重要的作用。Allergin-1 以单体形式存在，它与酪氨酸磷酸化蛋白（如 PTPN6、PTPN11 和 INPP5D）特异性相互作用。这种复杂的分子相互作用强调了 Allergin-1 在微调肥大细胞反应中的关键作用，有助于调节过敏反应和超敏反应的复杂调节机制。

Mouse

HEK293

C-hFc

Q3TB92 (M1-S150)

380732  [NCBI]

55-80 kDa.

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS,pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.