AMHR2/MISRII 蛋白, Mouse (HEK293, His)

AMHR2/MISRII Protein, upon ligand binding, assembles a receptor complex with two type II and two type I transmembrane serine/threonine kinases. Type II receptors initiate the signaling cascade by phosphorylating and activating type I receptors, which undergo autophosphorylation. Activated type I receptors then engage and activate SMAD transcriptional regulators, modulating downstream gene expression. Notably, AMHR2/MISRII serves as the receptor for anti-Muellerian hormone, playing a pivotal role in mediating cellular responses to this hormone. AMHR2/MISRII Protein, Mouse (HEK293, His) is the recombinant mouse-derived AMHR2/MISRII protein, expressed by HEK293, with C-His labeled tag. The total length of AMHR2/MISRII Protein, Mouse (HEK293, His) is 132 a.a., with molecular weight of approximately 25 kDa & 30 kDa, respectively.

AMHR2/MISRII 蛋白结合其配体后，会协调包含两种 II 型和两种 I 型跨膜丝氨酸/苏氨酸激酶的受体复合物的组装。II 型受体通过磷酸化和激活 I 型受体来启动信号级联，而 I 型受体又进行自身磷酸化。随后，这些激活的 I 型受体与 SMAD 转录调节因子结合并激活，最终调节下游基因表达。值得注意的是，AMHR2/MISRII 作为抗穆勒激素的受体，在介导该激素触发的细胞反应中发挥着关键作用。

Measured by its binding ability in a functional ELISA. Immobilized Human rhMIS at 3 μg/mL (100μL/well) can bind Biotinylated Mouse AMHR2. The ED₅₀ for this effect is 240.7 ng/mL.

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  Measured by its binding ability in a functional ELISA. Immobilized Human rhMIS at 3 μg/mL (100μL/well) can bind Biotinylated Mouse AMHR2 .The ED₅₀ for this effect is 240.7 ng/mL.

Mouse

HEK293

C-His

Q8K592 (Q16-M147)

110542  [NCBI]

QVSPNRRTCVFFEAPGVRGSTKTLGEMVDAGPGPPKGIRCLYSHCCFGIWNLTHGRAQVEMQGCRDSDEPGCESLHCDPVPRAHPNPSSTLFTCSCGTDFCNANYSHLPPSGNQGAPGPQEPQATPGGPVWM

approximately 25 kDa & 30 kDa

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized a 0.22 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.