Angiopoietin-1 蛋白, Mouse (HEK293, His)

Angiopoietin-1 (ANGPT1) is a secreted glycoprotein that belongs to the angiopoietin family. It actively regulates blood vessel formation and stabilization, playing a pivotal role in vascular development. ANGPT1 also influences skeletal myoblasts and orchestrates the vascular response to tissue injury. Its broad expression in various tissues highlights its significance in diverse physiological contexts. Angiopoietin-1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Angiopoietin-1 protein, expressed by HEK293 , with N-His labeled tag.

血管生成素-1 (ANGPT1) 编码血管生长因子血管生成素家族中的一种分泌糖蛋白。作为血管酪氨酸激酶信号通路中的重要配体，该蛋白积极调节血管的形成和稳定，显示出其在血管发育中的关键作用。除了其血管功能外，ANGPT1还在横纹肌中发挥作用，影响骨骼肌母细胞的增殖、迁移和分化。此外，ANGPT1 在协调血管对组织损伤的反应中发挥着至关重要的作用。该基因表现出选择性剪接，导致多种转录变体。它在各种组织中广泛表达，包括心脏、肺和其他解剖部位，强调了 ANGPT1 在不同生理环境中的重要性。

Measured by the ability of the immobilized protein to support the adhesion of HUVEC human umbilical vein endothelial cells. The ED₅₀ for this effect is 223.9 ng/mL, corresponding to a specific activity is 4.466×10^3 units/mg.

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  Measured by the ability of the immobilized protein to support the adhesion of HUVEC human umbilical vein endothelial cells. The ED₅₀ for this effect is 223.9 ng/mL, corresponding to a specific activity is 4.466×10³ units/mg.

Mouse

HEK293

N-6*His

NP_033770.2 (R277-F498)

11600

Partial

REEEKPFRDCADVYQAGFNKSGIYTIYFNNMPEPKKVFCNMDVNGGGWTVIQHREDGSLDFQRGWKEYKMGFGNPSGEYWLGNEFIFAITSQRQYMLRIELMDWEGNRAYSQYDRFHIGNEKQNYRLYLKGHTGTAGKQSSLILHGADFSTKDADNDNCMCKCALMLTGGWWFDACGPSNLNGMFYTAGQNHGKLNGIKWHYFKGPSYSLRSTTMMIRPLDF

Approximately 29 kDa

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.