ANGPTL2/Angiopoietin-like 2 蛋白, Mouse (HEK293, Fc)

ANGPTL2/Angiopoietin-like 2 protein plays a crucial role in inducing sprouting in endothelial cells through autocrine and paracrine mechanisms. It orchestrates angiogenic processes and regulates vascular development. ANGPTL2's versatile impact on endothelial cell behavior positions it as a key modulator in the molecular signals governing angiogenesis. ANGPTL2/Angiopoietin-like 2 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived ANGPTL2/Angiopoietin-like 2 protein, expressed by HEK293 , with N-hFc labeled tag. The total length of ANGPTL2/Angiopoietin-like 2 Protein, Mouse (HEK293, Fc) is 249 a.a., with molecular weight of ~58 kDa.

ANGPTL2/血管生成素样 2 蛋白通过自分泌和旁分泌机制在内皮细胞的出芽诱导中发挥着至关重要的作用。该蛋白质刺激新血管生长的能力反映了其在协调血管生成过程中的重要性。通过促进内皮细胞的出芽，ANGPTL2 有助于血管发育的动态调节，强调其参与血管生成发挥关键作用的基本生理和病理环境。ANGPTL2 的自分泌和旁分泌作用强调了其对内皮细胞行为的多种影响，将其定位为控制血管生成的复杂分子信号网络中的关键调节剂。

Measured by its binding ability in a functional ELISA. Immobilized Recombinant Mouse ANGPTL2/Angiopoietin-like 2 at 1 μg/mL (100 μL/well) can bind Recombinant Human ILT-4. The ED50 for this effect is 517.3 ng/mL.

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  Measured by its binding ability in a functional ELISA. Immobilized Recombinant Mouse ANGPTL2/Angiopoietin-like 2 at 1 μg/mL (100 μL/well) can bind Recombinant Human ILT-4.The ED₅₀ for this effect is 517.3ng/mL.

Mouse

HEK293

N-hFc

Q9R045 (D245-H493)

26360  [NCBI]

DQNLKVLPPSLPTMPALTSLPSSTDKPSGPWRDCLQALEDGHSTSSIYLVKPENTNRLMQVWCDQRHDPGGWTVIQRRLDGSVNFFRNWETYKQGFGNIDGEYWLGLENIYWLTNQGNYKLLVTMEDWSGRKVFAEYASFRLEPESEYYKLRLGRYHGNAGDSFTWHNGKQFTTLDRDHDVYTGNCAHYQKGGWWYNACAHSNLNGVWYRGGHYRSRYQDGVYWAEFRGGSYSLKKVVMMIRPNPNTFH

Approximately 58 kDa

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.