2. 重组蛋白
  3. Cytokines and Growth Factors
  4. Angiopoietins
  5. Angiopoietin-Like 7
  6. ANGPTL7/Angiopoietin-related 7 蛋白, Human (HEK293, hFc)

ANGPTL7/Angiopoietin-related 7 蛋白, Human (HEK293, hFc)

目录号: HY-P700852
产品使用指南

ANGPTL7/血管生成素相关7蛋白在细胞外基质的形成和组织中起着至关重要的作用。特别是在眼睛中，它充当地塞米松诱导的小梁网内基质沉积的介质，研究表明小梁网是房水流出和维持眼内压所必需的组织。ANGPTL7/Angiopoietin-related 7 蛋白, Human (HEK293, hFc) 是重组的 ANGPTL7/血管生成素相关 7 蛋白，由 HEK293 表达，带有 C-hFc 标签。ANGPTL7/Angiopoietin-related 7 蛋白, Human (HEK293, hFc) 全长 320 个氨基酸，分子量为 70-90 kDa。

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描述

ANGPTL7/angiopoietin-related 7 protein plays a crucial role in the formation and organization of the extracellular matrix. Particularly in the eye, it serves as a mediator for dexamethasone-induced matrix deposition within the trabecular meshwork, a tissue that studies have shown is necessary for aqueous humor outflow and maintenance of intraocular pressure. ANGPTL7/Angiopoietin-related 7 Protein, Human (HEK293, hFc) is the recombinant human-derived ANGPTL7/Angiopoietin-related 7 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of ANGPTL7/Angiopoietin-related 7 Protein, Human (HEK293, hFc) is 320 a.a., with molecular weight of 70-90 kDa.
研究背景

ANGPTL7/血管生成素相关 7 蛋白在细胞外基质的形成和组织中发挥着至关重要的作用。特别是在眼睛中，它充当地塞米松诱导的小梁网内基质沉积的介质，小梁网是眼房水流出和维持眼内压所必需的组织。此外，研究结果表明，ANGPTL7 作为角膜血管生成的负调节因子，在保持角膜无血管和透明度方面发挥着重要作用。在结构上，它通过二硫键形成同源四聚体，进一步强调了其在维持眼组织细胞外基质结构完整性方面的作用。
种属

Human
表达系统

HEK293
标签

C-hFc
蛋白编号

O43827 (Q27-P346)
基因 ID
蛋白结构
N-term
ANGPTL7 (Q27-P346)
Accession # O43827
hFc
C-term
同用名
angiopoietin-like 7; Angiopoietin-like factor; ANGPTL7; AngX; CDT6
分子量

70-90 kDa
纯度

Greater than 95% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

ANGPTL7/Angiopoietin-related 7 Protein, Human (HEK293, hFc) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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