Animal-Free BCA-1/CXCL13 蛋白, Human (His)

The BCA-1/CXCL13 protein selectively attracts B lymphocytes without affecting T lymphocytes, monocytes, or neutrophils. Unlike other chemokines, it does not induce calcium release from B lymphocytes. Animal-Free BCA-1/CXCL13 Protein, Human (His) is the recombinant human-derived animal-FreeBCA-1/CXCL13 protein, expressed by E. coli , with N-His labeled tag. The total length of Animal-Free BCA-1/CXCL13 Protein, Human (His) is 72 a.a., with molecular weight of ~9.49 kDa.

BCA-1/CXCL13 蛋白充当 B 淋巴细胞的选择性趋化因子，其作用与 T 淋巴细胞、单核细胞和中性粒细胞不同。与其他趋化因子不同，它不会诱导 B 淋巴细胞释放钙。其与 BLR1/CXCR5 的结合证明了其对 B 淋巴细胞的特异性，强调了其在协调 B 细胞迁移中的作用。这种趋化功能和受体结合的选择性使 BCA-1/CXCL13 成为免疫系统中的关键调节剂，有助于细胞微环境中 B 淋巴细胞的精确招募和激活。

Measure by its ability to chemoattract BaF3 cells transfected with human CXCR5. The ED₅₀ for this effect is <20 ng/mL.

Human

E. coli

N-His

O43927 (V23-R94)

10563  [NCBI]

VLEVYYTSLRCRCVQESSVFIPRRFIDRIQILPRGNGCPRKEIIVWKKNKSIVCVDPQAEWIQRMMEVLRKR

Approximately 9.49 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a solution containing 1X PBS, pH 7.4.

<0.1 EU per 1 μg of the protein by the LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US;may vary elsewhere.