Animal-Free ENA-78/CXCL5 蛋白, Human (His)

The CXCL5 protein is critical in neutrophil activation and displays enhanced chemotactic activity on neutrophils, with increased potency of ENA-78(8-78) and ENA-78(9-78) isoforms three times. Structurally, CXCL5 exists as monomers and homodimers, emphasizing its multifunctional molecular configuration. Animal-Free ENA-78/CXCL5 Protein, Human (His) is the recombinant human-derived animal-FreeENA-78/CXCL5 protein, expressed by E. coli , with N-His labeled tag. The total length of Animal-Free ENA-78/CXCL5 Protein, Human (His) is 70 a.a., with molecular weight of ~8.51 kDa.

CXCL5 蛋白在中性粒细胞激活中发挥着关键作用，在体外对中性粒细胞表现出增强的趋化活性，特别是其 ENA-78(8-78) 和 ENA-78(9-78) 亚型的趋化效力增加了三倍。在结构上，CXCL5 既以单体形式存在，也以同二聚体形式存在，强调了其分子构型的多功能性。这种双重性质表明它能够参与与中性粒细胞激活相关的独特相互作用和功能活动，突出了 CXCL5 在免疫反应调节中的关键作用。

Measure by its ability to chemoattract BaF3 cells transfected with human CXCR2. The ED₅₀ for this effect is <10 ng/mL.

Human

E. coli

N-His

P42830 (R45-N114)

6374  [NCBI]

RELRCVCLQTTQGVHPKMISNLQVFAIGPQCSKVEVVASLKNGKEICLDPEAPFLKKVIQKILDGGNKEN

Approximately 8.51 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a solution containing 1X PBS, pH 7.4.

<0.1 EU per 1 μg of the protein by the LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.