Animal-Free FGF-18 蛋白, Human (His)

FGF-18 Protein intricately regulates cell proliferation, differentiation, and migration, crucial in normal ossification and bone development for skeletal maturation. It stimulates hepatic and intestinal proliferation, showcasing versatile functions. Interactions with FGFR3 and FGFR4 underscore FGF-18 Protein's significance in modulating intricate signaling pathways for fundamental tissue development and homeostasis. Animal-Free FGF-18 Protein, Human (His) is the recombinant human-derived animal-FreeFGF-18 protein, expressed by E. coli, with C-His labeled tag. The total length of Animal-Free FGF-18 Protein, Human (His) is 173 a.a., with molecular weight of ~21.11 kDa.

FGF-18 蛋白在复杂的细胞增殖、分化和迁移调节中发挥着关键作用。它的不可或缺性延伸到正常骨化和骨骼发育的协调，强调它在骨骼成熟中的关键参与。此外，FGF-18 蛋白具有刺激肝脏和肠道增殖的能力，突出了其在不同组织中的多功能功能。这些细胞过程的介导是通过与 FGFR3 和 FGFR4 的相互作用来促进的，强调了 FGF-18 蛋白在调节复杂信号通路中的重要性，这些信号通路有助于组织发育和体内平衡的基本过程。

Measure by its ability to induce 3T3 cells proliferation. The ED₅₀ for this effect is 1.3-2.0 ng/mL. The specific activity of recombinant human FGF-18 is > 5 x 10⁵ IU/mg.

Human

E. coli

C-His

O76093 (A27-R199)

8817  [NCBI]

MAEENVDFRIHVENQTRARDDVSRKQLRLYQLYSRTSGKHIQVLGRRISARGEDGDKYAQLLVETDTFGSQVRIKGKETEFYLCMNRKGKLVGKPDGTSKECVFIEKVLENNYTALMSAKYSGWYVGFTKKGRPRKGPKTRENQQDVHFMKRYPKGQPELQKPFKYTTVTKRSR

Approximately 21.11 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a solution containing 1X PBS, pH 8.0.

<0.1 EU per 1 μg of the protein by the LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.