Animal-Free GRO-beta/CXCL2 蛋白, Human (His)

GRO-beta/CXCL2 Protein, generated by activated monocytes and neutrophils, is prominently expressed at inflammatory sites. Notably, this chemokine, with hematoregulatory properties, suppresses hematopoietic progenitor cell proliferation in vitro. GRO-beta(5-73) displays heightened hematopoietic activity, emphasizing its significant role in regulating hematopoiesis. Animal-Free GRO-beta/CXCL2 Protein, Human (His) is the recombinant human-derived animal-FreeGRO-beta/CXCL2 protein, expressed by E. coli, with N-His labeled tag. The total length of Animal-Free GRO-beta/CXCL2 Protein, Human (His) is 73 a.a., with molecular weight of ~8.7 kDa.

GRO-beta/CXCL2 由活化的单核细胞和中性粒细胞产生，在炎症部位显着表达。这种趋化因子表现出血液调节特性，因为已观察到它可以在体外抑制造血祖细胞的增殖。特别值得注意的是 GRO-beta(5-73) 显示出增强的造血活性，强调了其在调节造血功能中的重要作用。

Measure by its ability to chemoattract BaF3 cells transfected with human CXCR2. The ED₅₀ for this effect is <10 ng/mL.

Human

E. coli

N-His

P19875 (A35-N107)

2920  [NCBI]

APLATELRCQCLQTLQGIHLKNIQSVKVKSPGPHCAQTEVIATLKNGQKACLNPASPMVKKIIEKMLKNGKSN

Approximately 8.7 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a solution containing 1X PBS, pH 7.4.

<0.1 EU per 1 μg of the protein by the LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.