Animal-Free IL-16 蛋白, Mouse (His)

IL-16 is a modulator in inflammatory processes and tumorigenesis. IL16 can bind to the CD4 molecule and activate monocytes and stimulates the secretion of inflammatory cytokines. Besides, IL16 can induce expression of IL2Rα and β, and synergize with IL2 to augment CD4+ T cell activation and proliferation. IL16 can induce migration in CD4+ lymphocytes, monocytes, and eosinophils as a chemoattractant factor^[1][2][3]. Animal-Free IL-16 Protein, Mouse (His) is the recombinant mouse-derived animal-FreeIL-16 protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free IL-16 Protein, Mouse (His) is 126 a.a., with molecular weight of ~14.04 kDa.

IL-16 是一种多效细胞因子，是炎症过程和肿瘤发生的调节剂。IL16 可以与 CD4 分子结合并激活单核细胞并刺激炎症细胞因子的分泌，例如 TNF-α、IL1β、IL6 和 IL15^[1]。此外，IL16 可以诱导 IL2Rα 和 β 的表达，并与 IL2 协同增强 CD4+ T细胞的活化和增殖。此外，IL16 可作为趋化因子诱导 CD4+ 淋巴细胞、单核细胞和嗜酸性粒细胞迁移^[2]。
IL-16 在多种细胞中组成型表达，如 T 细胞、B 细胞、肥大细胞、嗜酸性粒细胞和上皮细胞^[2]。IL-16 主要由 CD4+ 和 CD8+ 细胞产生，作为前体蛋白 (pro-IL-16)。Pro-IL-16 被 caspase 3 酶促裂解，诱导释放具有生物活性的成熟形式的 IL-16^[3]。人 IL-16 与小鼠具有约 80% 的氨基酸序列同源性。

Mouse

E. coli

C-His

AAC04383.1 (H499-S624)

16170  [NCBI]

MHDLNSSTDSAASASAASDISVESKEATVCTVTLEKTSAGLGFSLEGGKGSLHGDKPLTINRIFKGDRTGEMVQPGDEILQLAGTAVQGLTRFEAWNVIKALPDGPVTIVIRRTSLQCKQTTASADS

Approximately 14.04 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a solution containing 1X PBS, pH 7.4.

<0.1 EU per 1 μg of the protein by the LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.