Animal-Free IL-17A 蛋白, Human (His)

The IL-17A protein is an important effector cytokine that is critical in both innate and adaptive immunity to defend against microorganisms and maintain tissue integrity. It acts through the IL17RA-IL17RC heterodimeric receptor complex, triggering signaling pathways, activating immune-related gene transcription and promoting strong immune inflammation. Animal-Free IL-17A Protein, Human (His) is the recombinant human-derived animal-FreeIL-17A protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free IL-17A Protein, Human (His) is 136 a.a., with molecular weight of ~16.47 kDa.

IL-17A 蛋白是先天性和适应性免疫反应中重要的效应细胞因子，在抗菌防御和组织完整性维护中发挥着至关重要的作用。它通过 IL17RA-IL17RC 异二聚体受体复合物运作，触发下游信号通路，导致免疫相关基因的转录激活和潜在的强烈免疫炎症。作为 Th17 细胞的标志性效应细胞因子，它诱导中性粒细胞在感染部位活化和募集，有助于宿主防御细胞外细菌和真菌。此外，异二聚体参与生发中心形成，介导趋化性，并在稳态和感染期间的上皮屏障维持中发挥重要作用。它形成同二聚体和异二聚体，展示了其在协调不同免疫过程中的多功能性。IL-17A 蛋白在连接 T 细胞介导的适应性免疫与急性炎症反应方面发挥着关键作用，突显了其在免疫调节和细胞稳态中的多方面作用。

Measure by its ability to induce IL-6 secretion in 3T3 cells. The ED₅₀ for this effect is <6 ng/mL.

Human

E. coli

C-His

Q16552 (I20-A155)

3605  [NCBI]

MIVKAGITIPRNPGCPNSEDKNFPRTVMVNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQEILVLRREPPHCPNSFRLEKILVSVGCTCVTPIVHHVA

Approximately 16.47 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a solution containing 1X PBS, pH 8.0.

<0.01 EU per 1 μg of the protein by the LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.